Less is more: Caloric regulation of neurogenesis and adult brain function

A. H. Morgan, Z. B. Andrews, J. S. Davies

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)


Calorie intake is essential for regulating normal physiological processes and is fundamental to maintaining life. Indeed, both extremes of calorie intake result in increased morbidity and mortality. In this review, we discuss the effect of calorie intake on adult brain function, with an emphasis on the beneficial effects of mild calorie restriction. Recent findings relating to the regenerative and protective effects of the gastrointestinal hormone, ghrelin, suggest that it may underlie the beneficial effects of calorie restriction. We discuss the putative cellular mechanisms underlying the action of ghrelin and their possible role in supporting healthy brain ageing.

Original languageEnglish
Article numbere12512
Number of pages11
JournalJournal of Neuroendocrinology
Issue number10
Publication statusPublished - 1 Oct 2017


  • acyl-ghrelin
  • adult hippocampal neurogenesis
  • calorie restriction
  • diet-induced obesity

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