Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.

Original languageEnglish
Pages (from-to)346-355
Number of pages10
JournalCell Reports
Volume26
Issue number2
DOIs
Publication statusPublished - 8 Jan 2019

Keywords

  • arcuate nucleus
  • diet-induced obesity
  • glucose homeostasis
  • hepatic glucose production
  • hyperglycemia
  • hypothalamus
  • insulin
  • leptin
  • protein tyrosine phosphatase 1B
  • type 2 diabetes

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