Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Eglantine Balland; Weiyi Chen; Garron T. Dodd; Gregory Conductier; Roberto Coppari; Tony Tiganis; Michael A. Cowley

doi:10.1016/j.celrep.2018.12.061

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.

Original language	English
Pages (from-to)	346-355
Number of pages	10
Journal	Cell Reports
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2018.12.061
Publication status	Published - 8 Jan 2019

Keywords

arcuate nucleus
diet-induced obesity
glucose homeostasis
hepatic glucose production
hyperglycemia
hypothalamus
insulin
leptin
protein tyrosine phosphatase 1B
type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.celrep.2018.12.061

259142581-oaFinal published version, 2.27 MB

Cite this

@article{7a93167b961242b9b829107f15d670e6,

title = "Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice",

abstract = "Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.",

keywords = "arcuate nucleus, diet-induced obesity, glucose homeostasis, hepatic glucose production, hyperglycemia, hypothalamus, insulin, leptin, protein tyrosine phosphatase 1B, type 2 diabetes",

author = "Eglantine Balland and Weiyi Chen and Dodd, {Garron T.} and Gregory Conductier and Roberto Coppari and Tony Tiganis and Cowley, {Michael A.}",

year = "2019",

month = jan,

day = "8",

doi = "10.1016/j.celrep.2018.12.061",

language = "English",

volume = "26",

pages = "346--355",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

AU - Balland, Eglantine

AU - Chen, Weiyi

AU - Dodd, Garron T.

AU - Conductier, Gregory

AU - Coppari, Roberto

AU - Tiganis, Tony

AU - Cowley, Michael A.

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.

AB - Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.

KW - arcuate nucleus

KW - diet-induced obesity

KW - glucose homeostasis

KW - hepatic glucose production

KW - hyperglycemia

KW - hypothalamus

KW - insulin

KW - leptin

KW - protein tyrosine phosphatase 1B

KW - type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85059342368&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2018.12.061

DO - 10.1016/j.celrep.2018.12.061

M3 - Article

AN - SCOPUS:85059342368

SN - 2211-1247

VL - 26

SP - 346

EP - 355

JO - Cell Reports

JF - Cell Reports

IS - 2

ER -

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice

Cardiovascular effects of enhanced leptin signalling

PTPs in the CNS control of WAT browning

NHMRC Research Fellowship

Cite this

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Research output

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice

Projects

Cardiovascular effects of enhanced leptin signalling

PTPs in the CNS control of WAT browning

NHMRC Research Fellowship

Cite this