Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)


Balland et al. identify a molecular link between obesity and type 2 diabetes by demonstrating that, in obesity, leptin signaling in the CNS impairs the regulation of hepatic glucose production, leading to hyperglycemia.

Original languageEnglish
Pages (from-to)346-355
Number of pages10
JournalCell Reports
Issue number2
Publication statusPublished - 8 Jan 2019


  • arcuate nucleus
  • diet-induced obesity
  • glucose homeostasis
  • hepatic glucose production
  • hyperglycemia
  • hypothalamus
  • insulin
  • leptin
  • protein tyrosine phosphatase 1B
  • type 2 diabetes

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