Leptin resistance and obesity.

Pablo J. Enriori, Anne E. Evans, Puspha Sinnayah, Michael A. Cowley

Research output: Contribution to journalReview ArticleResearchpeer-review

191 Citations (Scopus)


The prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake. In common obesity, leptin loses the ability to inhibit energy intake and increase energy expenditure; this is termed leptin resistance. This review discusses the evidence in support of leptin resistance in mouse models and humans and the possible mechanisms of leptin resistance.

Original languageEnglish
Volume14 Suppl 5
Publication statusPublished - 1 Aug 2006

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