Lenalidomide in multiple myeloma: current status and future potential

Hang Quach, Anna Kalff, Andrew Spencer

    Research output: Contribution to journalArticleResearchpeer-review

    20 Citations (Scopus)

    Abstract

    The clinical development of lenalidomide (Revlimid?), then pomalidomide (Actimid?) as members of immunomodulatory drugs (IMiDs) for the treatment of multiple myeloma (MM), exemplifies how insight into disease biology can lead to design of effective therapeutic agents. Increased experience and understanding of IMiD s diverse biological effects has lead to rational design of lenalidomide-based treatment-regimens over recent years. However, much about lenalidomide is yet to be understood and fully exploited. Here, we review what is known of lenalidomide s biological effects, clinical certainties and uncertainties in the treatment of MM, and explore its future potential with other synergistic therapeutic agents. ? 2012 Wiley Periodicals, Inc.
    Original languageEnglish
    Pages (from-to)1089 - 1095
    Number of pages7
    JournalAmerican Journal of Hematology
    Volume87
    Issue number12
    DOIs
    Publication statusPublished - 2012

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