Learning from Peptides to Access Functional Precision Polymer Sequences

Eva Maron, Jordan H. Swisher, Joris J. Haven, Tara Y. Meyer, Tanja Junkers, Hans G. Börner

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Functional precision polymers based on monodisperse oligo(N-substituted acrylamide)s and oligo(2-substituted-α-hydroxy acid)s have been synthesized. The discrete sequences originate from a direct translation of side-chain functionality sequences of a peptide with well-studied properties. The peptide was previously selected to solubilize the photosensitizer meta-tetra(hydroxyphenyl)chlorin. The resulting peptidomimetic formulation additives preserve the drug solubilization and release characteristics of the parent peptide. In some cases, superior properties are obtained, reaching up to 40 % higher payloads and 27-times faster initial drug release.

Original languageEnglish
Pages (from-to)10747-10751
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number31
DOIs
Publication statusPublished - 29 Jul 2019

Keywords

  • drug delivery system
  • monodisperse polymers
  • peptide PEG conjugates
  • precision polymers
  • sequence design

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