TY - JOUR
T1 - Learning and memory-related brain activity dynamics are altered in systemic lupus erythematosus: a functional magnetic resonance imaging study
AU - Shapira-Lichter, Irit
AU - Vakil, Eli
AU - Litinsky, Ira
AU - Oren, Noga
AU - Glikmann-Johnston, Yifat
AU - Caspi, Dan
AU - Hendler, Talma
AU - Paran, Daphna
PY - 2013
Y1 - 2013
N2 - Background: Memory impairment is prevalent in systemic lupus erythematosus (SLE); however, the pathogenesis is unknown. Methods: We studied 12 patients with SLE without clinically overt neuropsychiatric manifestations and 11 matched healthy controls, aiming to characterize neural correlates of memory impairment, using structural and functional magnetic resonance imaging (MRI). The paradigm consisted of three encoding and free-recall cycles, allowing characterization of dynamics along consecutive retrieval attempts. Results: During learning, patients with SLE and healthy controls showed brain activity changes in two principal networks, the default mode network (DMN) and the task-positive network (TPN). Patients with SLE demonstrated significantly less deactivation in the DMN and greater activation in the TPN, reflecting greater recruitment of both networks. The anterior medial prefrontal cortex (amPFC) of the DMN emerged as the only region where brain activity dynamics were altered both over the learning process (p
AB - Background: Memory impairment is prevalent in systemic lupus erythematosus (SLE); however, the pathogenesis is unknown. Methods: We studied 12 patients with SLE without clinically overt neuropsychiatric manifestations and 11 matched healthy controls, aiming to characterize neural correlates of memory impairment, using structural and functional magnetic resonance imaging (MRI). The paradigm consisted of three encoding and free-recall cycles, allowing characterization of dynamics along consecutive retrieval attempts. Results: During learning, patients with SLE and healthy controls showed brain activity changes in two principal networks, the default mode network (DMN) and the task-positive network (TPN). Patients with SLE demonstrated significantly less deactivation in the DMN and greater activation in the TPN, reflecting greater recruitment of both networks. The anterior medial prefrontal cortex (amPFC) of the DMN emerged as the only region where brain activity dynamics were altered both over the learning process (p
UR - http://lup.sagepub.com/content/22/6/562.full.pdf+html
U2 - 10.1177/0961203313480399
DO - 10.1177/0961203313480399
M3 - Article
SN - 0961-2033
VL - 22
SP - 562
EP - 573
JO - Lupus
JF - Lupus
IS - 6
ER -