Leaching of 2‐(2‐hydroxyethylmercapto)benzothiazole into contents of disposable syringes

Marisa C. Petersen, John Vine, John J. Ashley, Roger L. Nation

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A contaminant was found to leach into the contents of two brands of disposable syringes. It was identified as 2‐(2‐hydroxyethyl‐mercapto)benzothiazole and is believed to be formed during manufacture of the syringes as a result of a reaction between 2‐mercaptobenzothiazole, a rubber vulcanization accelerator, and ethylene oxide, used for sterilization. The contaminant was isolated from the rubber plunger‐seal and identified using mass, NMR, and UV spectroscopic methods. The amount of contaminant appearing in the contents of syringes was measured; up to 140 μg was found under clinically relevant conditions. This finding has important implications with respect to the use of these syringes for drug administration and for the collection of blood for drug analyses.

Original languageEnglish
Pages (from-to)1139-1143
Number of pages5
JournalJournal of Pharmaceutical Sciences
Issue number10
Publication statusPublished - 1 Jan 1981


  • 2‐(2‐Hydroxyethylmercapto)benzothiazole—leaching into contents of disposable syringes, isolation, identification, and quantitation
  • Contaminants—2‐(2‐hydroxyethylmercapto)benzothiazole, leaching from disposable syringes
  • Syringes, disposable—leaching of 2‐(2‐hydroxyethyl‐mercapto)benzothiazole, isolation, identification, and quantitation

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