Leaching of 2‐(2‐hydroxyethylmercapto)benzothiazole into contents of disposable syringes

Marisa C. Petersen, John Vine, John J. Ashley, Roger L. Nation

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A contaminant was found to leach into the contents of two brands of disposable syringes. It was identified as 2‐(2‐hydroxyethyl‐mercapto)benzothiazole and is believed to be formed during manufacture of the syringes as a result of a reaction between 2‐mercaptobenzothiazole, a rubber vulcanization accelerator, and ethylene oxide, used for sterilization. The contaminant was isolated from the rubber plunger‐seal and identified using mass, NMR, and UV spectroscopic methods. The amount of contaminant appearing in the contents of syringes was measured; up to 140 μg was found under clinically relevant conditions. This finding has important implications with respect to the use of these syringes for drug administration and for the collection of blood for drug analyses.

Original languageEnglish
Pages (from-to)1139-1143
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume70
Issue number10
DOIs
Publication statusPublished - 1 Jan 1981

Keywords

  • 2‐(2‐Hydroxyethylmercapto)benzothiazole—leaching into contents of disposable syringes, isolation, identification, and quantitation
  • Contaminants—2‐(2‐hydroxyethylmercapto)benzothiazole, leaching from disposable syringes
  • Syringes, disposable—leaching of 2‐(2‐hydroxyethyl‐mercapto)benzothiazole, isolation, identification, and quantitation

Cite this

Petersen, Marisa C. ; Vine, John ; Ashley, John J. ; Nation, Roger L. / Leaching of 2‐(2‐hydroxyethylmercapto)benzothiazole into contents of disposable syringes. In: Journal of Pharmaceutical Sciences. 1981 ; Vol. 70, No. 10. pp. 1139-1143.
@article{26bc67911c9f4e94aef351793f65bb3f,
title = "Leaching of 2‐(2‐hydroxyethylmercapto)benzothiazole into contents of disposable syringes",
abstract = "A contaminant was found to leach into the contents of two brands of disposable syringes. It was identified as 2‐(2‐hydroxyethyl‐mercapto)benzothiazole and is believed to be formed during manufacture of the syringes as a result of a reaction between 2‐mercaptobenzothiazole, a rubber vulcanization accelerator, and ethylene oxide, used for sterilization. The contaminant was isolated from the rubber plunger‐seal and identified using mass, NMR, and UV spectroscopic methods. The amount of contaminant appearing in the contents of syringes was measured; up to 140 μg was found under clinically relevant conditions. This finding has important implications with respect to the use of these syringes for drug administration and for the collection of blood for drug analyses.",
keywords = "2‐(2‐Hydroxyethylmercapto)benzothiazole—leaching into contents of disposable syringes, isolation, identification, and quantitation, Contaminants—2‐(2‐hydroxyethylmercapto)benzothiazole, leaching from disposable syringes, Syringes, disposable—leaching of 2‐(2‐hydroxyethyl‐mercapto)benzothiazole, isolation, identification, and quantitation",
author = "Petersen, {Marisa C.} and John Vine and Ashley, {John J.} and Nation, {Roger L.}",
year = "1981",
month = "1",
day = "1",
doi = "10.1002/jps.2600701012",
language = "English",
volume = "70",
pages = "1139--1143",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "10",

}

Leaching of 2‐(2‐hydroxyethylmercapto)benzothiazole into contents of disposable syringes. / Petersen, Marisa C.; Vine, John; Ashley, John J.; Nation, Roger L.

In: Journal of Pharmaceutical Sciences, Vol. 70, No. 10, 01.01.1981, p. 1139-1143.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Leaching of 2‐(2‐hydroxyethylmercapto)benzothiazole into contents of disposable syringes

AU - Petersen, Marisa C.

AU - Vine, John

AU - Ashley, John J.

AU - Nation, Roger L.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - A contaminant was found to leach into the contents of two brands of disposable syringes. It was identified as 2‐(2‐hydroxyethyl‐mercapto)benzothiazole and is believed to be formed during manufacture of the syringes as a result of a reaction between 2‐mercaptobenzothiazole, a rubber vulcanization accelerator, and ethylene oxide, used for sterilization. The contaminant was isolated from the rubber plunger‐seal and identified using mass, NMR, and UV spectroscopic methods. The amount of contaminant appearing in the contents of syringes was measured; up to 140 μg was found under clinically relevant conditions. This finding has important implications with respect to the use of these syringes for drug administration and for the collection of blood for drug analyses.

AB - A contaminant was found to leach into the contents of two brands of disposable syringes. It was identified as 2‐(2‐hydroxyethyl‐mercapto)benzothiazole and is believed to be formed during manufacture of the syringes as a result of a reaction between 2‐mercaptobenzothiazole, a rubber vulcanization accelerator, and ethylene oxide, used for sterilization. The contaminant was isolated from the rubber plunger‐seal and identified using mass, NMR, and UV spectroscopic methods. The amount of contaminant appearing in the contents of syringes was measured; up to 140 μg was found under clinically relevant conditions. This finding has important implications with respect to the use of these syringes for drug administration and for the collection of blood for drug analyses.

KW - 2‐(2‐Hydroxyethylmercapto)benzothiazole—leaching into contents of disposable syringes, isolation, identification, and quantitation

KW - Contaminants—2‐(2‐hydroxyethylmercapto)benzothiazole, leaching from disposable syringes

KW - Syringes, disposable—leaching of 2‐(2‐hydroxyethyl‐mercapto)benzothiazole, isolation, identification, and quantitation

UR - http://www.scopus.com/inward/record.url?scp=0019773473&partnerID=8YFLogxK

U2 - 10.1002/jps.2600701012

DO - 10.1002/jps.2600701012

M3 - Article

VL - 70

SP - 1139

EP - 1143

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 10

ER -