TY - JOUR
T1 - LDL particle size in subjects with previously unsuspected coronary heart disease
T2 - Relationship with other cardiovascular risk markers
AU - Sherrard, Bridget
AU - Simpson, Harrison
AU - Cameron, James
AU - Wahi, Sudir
AU - Jennings, Garry
AU - Dart, Anthony
PY - 1996/10/25
Y1 - 1996/10/25
N2 - Low density lipoprotein (LDL) particle diameters were determined by non-denaturing gradient gel electrophoresis in 53 subjects with previously unrecognised coronary heart disease (CHD) and 167 control subjects matched by age, sex and total plasma cholesterol. The mean diameter of the major LDL peak was found not to be significantly different between the two groups, but the CHD subjects were found to have a broader distribution of the predominant LDL species ((25.0 (24.7-25.3)nm versus 24.8 (24.7-24.9)nm)) (median (25-75%)), a greater proportion of larger particles (χ2 = 19.8, P < 0.001) and to be more likely to have multiple numbers of LDL species than the control subjects (χ2 = 22.7, P < 0.001). A negative correlation was found between the diameter of the predominant LDL species and fasting plasma triglyceride (r = -0.21, P = 0.0015), waist to hip ratio (WHR) (r = -0.15, P = 0.026) and body mass index (BMI) (r = - 0.20, P = 0.002), and in a subgroup of subjects (n = 106), postprandial analysis revealed a negative correlation with the incremental postprandial response of plasma insulin (r = - 0.19, P = 0.025). Male subjects had a significantly smaller diameter of the major LDL peak (24.8 ± 0.0 nm) than female subjects (25.0 ± 0.0 nm, P < 0.001). The present study failed to confirm an association between small LDL particles and the presence of coronary heart disease but did demonstrate more LDL heterogeneity in those with CHD. In addition, significant relationships were evident between the diameter of the major LDL peak and a number of other risk factors for coronary disease.
AB - Low density lipoprotein (LDL) particle diameters were determined by non-denaturing gradient gel electrophoresis in 53 subjects with previously unrecognised coronary heart disease (CHD) and 167 control subjects matched by age, sex and total plasma cholesterol. The mean diameter of the major LDL peak was found not to be significantly different between the two groups, but the CHD subjects were found to have a broader distribution of the predominant LDL species ((25.0 (24.7-25.3)nm versus 24.8 (24.7-24.9)nm)) (median (25-75%)), a greater proportion of larger particles (χ2 = 19.8, P < 0.001) and to be more likely to have multiple numbers of LDL species than the control subjects (χ2 = 22.7, P < 0.001). A negative correlation was found between the diameter of the predominant LDL species and fasting plasma triglyceride (r = -0.21, P = 0.0015), waist to hip ratio (WHR) (r = -0.15, P = 0.026) and body mass index (BMI) (r = - 0.20, P = 0.002), and in a subgroup of subjects (n = 106), postprandial analysis revealed a negative correlation with the incremental postprandial response of plasma insulin (r = - 0.19, P = 0.025). Male subjects had a significantly smaller diameter of the major LDL peak (24.8 ± 0.0 nm) than female subjects (25.0 ± 0.0 nm, P < 0.001). The present study failed to confirm an association between small LDL particles and the presence of coronary heart disease but did demonstrate more LDL heterogeneity in those with CHD. In addition, significant relationships were evident between the diameter of the major LDL peak and a number of other risk factors for coronary disease.
KW - Coronary heart disease
KW - Glucose
KW - Insulin
KW - Low density lipoprotein particle size
KW - Triglyceride
UR - http://www.scopus.com/inward/record.url?scp=0030601713&partnerID=8YFLogxK
U2 - 10.1016/0021-9150(96)05920-5
DO - 10.1016/0021-9150(96)05920-5
M3 - Article
C2 - 8902153
AN - SCOPUS:0030601713
VL - 126
SP - 277
EP - 287
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -