LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Wei Guang Wang; Ao Li; Bing Chao Yan; Shu Bin Niu; Jian Wei Tang; Xiao Nian Li; Xue Du; Gregory L. Challis; Yongsheng Che; Han Dong Sun; Jian Xin Pu

doi:10.1021/acs.jnatprod.5b00814

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Wei Guang Wang
, Ao Li
, Bing Chao Yan
, Shu Bin Niu
, Jian Wei Tang
, Xiao Nian Li
, Xue Du
, Gregory L. Challis
, Yongsheng Che
, Han Dong Sun
, Jian Xin Pu

Research output: Contribution to journal › Article › Research › peer-review

36 Citations (Scopus)

Abstract

Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.

Original language	English
Pages (from-to)	149-155
Number of pages	7
Journal	Journal of Natural Products
Volume	79
Issue number	1
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00814
Publication status	Published - 22 Jan 2016
Externally published	Yes

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10.1021/acs.jnatprod.5b00814

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title = "LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18",

abstract = "Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.",

author = "Wang, \{Wei Guang\} and Ao Li and Yan, \{Bing Chao\} and Niu, \{Shu Bin\} and Tang, \{Jian Wei\} and Li, \{Xiao Nian\} and Xue Du and Challis, \{Gregory L.\} and Yongsheng Che and Sun, \{Han Dong\} and Pu, \{Jian Xin\}",

year = "2016",

month = jan,

day = "22",

doi = "10.1021/acs.jnatprod.5b00814",

language = "English",

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journal = "Journal of Natural Products",

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T1 - LC-MS-Guided Isolation of Penicilfuranone A

T2 - A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

AU - Wang, Wei Guang

AU - Li, Ao

AU - Yan, Bing Chao

AU - Niu, Shu Bin

AU - Tang, Jian Wei

AU - Li, Xiao Nian

AU - Du, Xue

AU - Challis, Gregory L.

AU - Che, Yongsheng

AU - Sun, Han Dong

AU - Pu, Jian Xin

PY - 2016/1/22

Y1 - 2016/1/22

N2 - Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.

AB - Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.

UR - https://www.scopus.com/pages/publications/84956801784

U2 - 10.1021/acs.jnatprod.5b00814

DO - 10.1021/acs.jnatprod.5b00814

M3 - Article

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AN - SCOPUS:84956801784

SN - 0163-3864

VL - 79

SP - 149

EP - 155

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Abstract

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