LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Wei Guang Wang, Ao Li, Bing Chao Yan, Shu Bin Niu, Jian Wei Tang, Xiao Nian Li, Xue Du, Gregory L. Challis, Yongsheng Che, Han Dong Sun, Jian Xin Pu

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Abstract

Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalJournal of Natural Products
Volume79
Issue number1
DOIs
Publication statusPublished - 22 Jan 2016
Externally publishedYes

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