Abstract
Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.
Original language | English |
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Pages (from-to) | 149-155 |
Number of pages | 7 |
Journal | Journal of Natural Products |
Volume | 79 |
Issue number | 1 |
DOIs | |
Publication status | Published - 22 Jan 2016 |
Externally published | Yes |