Layer-by-layer-assembled capsules and films for therapeutic delivery

Alisa L Becker, Angus Johnston, Frank Caruso

Research output: Contribution to journalArticleResearchpeer-review

291 Citations (Scopus)

Abstract

Polymeric materials formed via layer-by-layer (LbL) assembly have promise for use as drug delivery vehicles. These multilayered materials, both as capsules and thin fi lms, can encapsulate a high payload of toxic or sensitive drugs, and can be readily engineered and functionalized with specifi c properties. This review highlights important and recent studies that advance the use of LbL-assembled materials as therapeutic devices. It also seeks to identify areas that require additional investigation for future development of the fi eld. A variety of drug-loading methods and delivery routes are discussed. The biological barriers to successful delivery are identifi ed, and possible solutions to these problems are discussed. Finally, state-of-the-art degradation and cargo release mechanisms are also presented.
Original languageEnglish
Pages (from-to)1836 - 1852
Number of pages17
JournalSmall
Volume6
Issue number17
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this