Abstract
Polymeric materials formed via layer-by-layer (LbL) assembly have promise for use as drug delivery vehicles. These multilayered materials, both as capsules and thin fi lms, can encapsulate a high payload of toxic or sensitive drugs, and can be readily engineered and functionalized with specifi c properties. This review highlights important and recent studies that advance the use of LbL-assembled materials as therapeutic devices. It also seeks to identify areas that require additional investigation for future development of the fi eld. A variety of drug-loading methods and delivery routes are discussed. The biological barriers to successful delivery are identifi ed, and possible solutions to these problems are discussed. Finally, state-of-the-art degradation and cargo release mechanisms are also presented.
Original language | English |
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Pages (from-to) | 1836 - 1852 |
Number of pages | 17 |
Journal | Small |
Volume | 6 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |