Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism

James T H Teo, Graham D Bentley, Philip Lawrence, Fruzsina Soltesz, Sam Miller, David R Wille, Simon McHugh, Chris M Dodds, Bai Lu, Rodney James Croft, Edward Bullmore, Pradeep Jonathan Nathan

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18 Citations (Scopus)

Abstract

Abstract The brain-derived neurotropic factor (BDNF) Val66Met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. No study has yet been done on plasticity in non-motor regions, and the effect of two Met alleles (i.e. Met dose ) is not well understood. We studied the effect of the BDNF Val66Met polymorphism on the after-effects of transcranial direct current stimulation and tetanic auditory stimulation in 65 subjects (23; Val66Val, 22; Val66Met and 20; Met66Met genotypes). In the first session, motor evoked potentials (MEP) were recorded under stereotaxic guidance for 90 min after 9 min of anodal transcranial direct current stimulation (TDCS). In the second session, auditory-evoked potentials (AEP) were recorded before and after 2 min of auditory 13 Hz tetanic stimulation. There was a difference in MEP facilitation post-TDCS comparing Met carriers with non-Met carriers, with Met carriers having a modest late facilitation at 30-90 min. There was no difference in responses between Val66Met genotype and Met66Met genotype subjects. Tetanic auditory stimulation also produced late facilitation of N1-P2 AEP at 25 min, but there was no apparent effect of genetic status. This study indicates that Met66Met carriers behave like Val66Met carriers for TDCS-induced plasticity, and produce a late facilitation of MEPs. Auditory cortical plasticity was not affected by the BDNF Val66Met polymorphism. This study sheds light on the differences between auditory and motor cortical plasticity and the role of the BDNF Val66Met polymorphism
Original languageEnglish
Pages (from-to)705 - 713
Number of pages9
JournalInternational Journal of Neuropsychopharmacology
Volume17
Issue number5
DOIs
Publication statusPublished - 2014

Cite this

Teo, James T H ; Bentley, Graham D ; Lawrence, Philip ; Soltesz, Fruzsina ; Miller, Sam ; Wille, David R ; McHugh, Simon ; Dodds, Chris M ; Lu, Bai ; Croft, Rodney James ; Bullmore, Edward ; Nathan, Pradeep Jonathan. / Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism. In: International Journal of Neuropsychopharmacology. 2014 ; Vol. 17, No. 5. pp. 705 - 713.
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abstract = "Abstract The brain-derived neurotropic factor (BDNF) Val66Met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. No study has yet been done on plasticity in non-motor regions, and the effect of two Met alleles (i.e. Met dose ) is not well understood. We studied the effect of the BDNF Val66Met polymorphism on the after-effects of transcranial direct current stimulation and tetanic auditory stimulation in 65 subjects (23; Val66Val, 22; Val66Met and 20; Met66Met genotypes). In the first session, motor evoked potentials (MEP) were recorded under stereotaxic guidance for 90 min after 9 min of anodal transcranial direct current stimulation (TDCS). In the second session, auditory-evoked potentials (AEP) were recorded before and after 2 min of auditory 13 Hz tetanic stimulation. There was a difference in MEP facilitation post-TDCS comparing Met carriers with non-Met carriers, with Met carriers having a modest late facilitation at 30-90 min. There was no difference in responses between Val66Met genotype and Met66Met genotype subjects. Tetanic auditory stimulation also produced late facilitation of N1-P2 AEP at 25 min, but there was no apparent effect of genetic status. This study indicates that Met66Met carriers behave like Val66Met carriers for TDCS-induced plasticity, and produce a late facilitation of MEPs. Auditory cortical plasticity was not affected by the BDNF Val66Met polymorphism. This study sheds light on the differences between auditory and motor cortical plasticity and the role of the BDNF Val66Met polymorphism",
author = "Teo, {James T H} and Bentley, {Graham D} and Philip Lawrence and Fruzsina Soltesz and Sam Miller and Wille, {David R} and Simon McHugh and Dodds, {Chris M} and Bai Lu and Croft, {Rodney James} and Edward Bullmore and Nathan, {Pradeep Jonathan}",
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language = "English",
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Teo, JTH, Bentley, GD, Lawrence, P, Soltesz, F, Miller, S, Wille, DR, McHugh, S, Dodds, CM, Lu, B, Croft, RJ, Bullmore, E & Nathan, PJ 2014, 'Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism', International Journal of Neuropsychopharmacology, vol. 17, no. 5, pp. 705 - 713. https://doi.org/10.1017/S146114571300163

Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism. / Teo, James T H; Bentley, Graham D; Lawrence, Philip; Soltesz, Fruzsina; Miller, Sam; Wille, David R; McHugh, Simon; Dodds, Chris M; Lu, Bai; Croft, Rodney James; Bullmore, Edward; Nathan, Pradeep Jonathan.

In: International Journal of Neuropsychopharmacology, Vol. 17, No. 5, 2014, p. 705 - 713.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism

AU - Teo, James T H

AU - Bentley, Graham D

AU - Lawrence, Philip

AU - Soltesz, Fruzsina

AU - Miller, Sam

AU - Wille, David R

AU - McHugh, Simon

AU - Dodds, Chris M

AU - Lu, Bai

AU - Croft, Rodney James

AU - Bullmore, Edward

AU - Nathan, Pradeep Jonathan

PY - 2014

Y1 - 2014

N2 - Abstract The brain-derived neurotropic factor (BDNF) Val66Met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. No study has yet been done on plasticity in non-motor regions, and the effect of two Met alleles (i.e. Met dose ) is not well understood. We studied the effect of the BDNF Val66Met polymorphism on the after-effects of transcranial direct current stimulation and tetanic auditory stimulation in 65 subjects (23; Val66Val, 22; Val66Met and 20; Met66Met genotypes). In the first session, motor evoked potentials (MEP) were recorded under stereotaxic guidance for 90 min after 9 min of anodal transcranial direct current stimulation (TDCS). In the second session, auditory-evoked potentials (AEP) were recorded before and after 2 min of auditory 13 Hz tetanic stimulation. There was a difference in MEP facilitation post-TDCS comparing Met carriers with non-Met carriers, with Met carriers having a modest late facilitation at 30-90 min. There was no difference in responses between Val66Met genotype and Met66Met genotype subjects. Tetanic auditory stimulation also produced late facilitation of N1-P2 AEP at 25 min, but there was no apparent effect of genetic status. This study indicates that Met66Met carriers behave like Val66Met carriers for TDCS-induced plasticity, and produce a late facilitation of MEPs. Auditory cortical plasticity was not affected by the BDNF Val66Met polymorphism. This study sheds light on the differences between auditory and motor cortical plasticity and the role of the BDNF Val66Met polymorphism

AB - Abstract The brain-derived neurotropic factor (BDNF) Val66Met polymorphism has been associated with abnormalities of synaptic plasticity in animal models, and abnormalities in motor cortical plasticity have also been described in humans using transcranial direct current stimulation. No study has yet been done on plasticity in non-motor regions, and the effect of two Met alleles (i.e. Met dose ) is not well understood. We studied the effect of the BDNF Val66Met polymorphism on the after-effects of transcranial direct current stimulation and tetanic auditory stimulation in 65 subjects (23; Val66Val, 22; Val66Met and 20; Met66Met genotypes). In the first session, motor evoked potentials (MEP) were recorded under stereotaxic guidance for 90 min after 9 min of anodal transcranial direct current stimulation (TDCS). In the second session, auditory-evoked potentials (AEP) were recorded before and after 2 min of auditory 13 Hz tetanic stimulation. There was a difference in MEP facilitation post-TDCS comparing Met carriers with non-Met carriers, with Met carriers having a modest late facilitation at 30-90 min. There was no difference in responses between Val66Met genotype and Met66Met genotype subjects. Tetanic auditory stimulation also produced late facilitation of N1-P2 AEP at 25 min, but there was no apparent effect of genetic status. This study indicates that Met66Met carriers behave like Val66Met carriers for TDCS-induced plasticity, and produce a late facilitation of MEPs. Auditory cortical plasticity was not affected by the BDNF Val66Met polymorphism. This study sheds light on the differences between auditory and motor cortical plasticity and the role of the BDNF Val66Met polymorphism

UR - http://ijnp.oxfordjournals.org/content/17/5/705.full-text.pdf

U2 - 10.1017/S146114571300163

DO - 10.1017/S146114571300163

M3 - Article

VL - 17

SP - 705

EP - 713

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - 5

ER -