Large deformations of elastic vessels under atherosclerotic conditions

Pauline Assemat, Kerry Hourigan

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Cardiovascular diseases remain the major cause of mortality worldwide. Pathologies of the vasculature such as atherosclerosis are often related to biochemical and genetic factors, as well as mechanical effects that strongly change the function and shape of arteries. The present work is part of a general research project that aims to understand better the mechanical mechanisms responsible for atherosclerotic plaque formation and rupture. The chosen approach is to use numerical fluid structure interaction (FSI) methods to study the relative influence of the hemodynamical stresses and the structural stresses generated on plaques, in combination with an experimental approach to validate the results. To meet this aim, a numerical study of a simplified straight vessel exposed to lumen pressure was investigated under quiescent, steady and oscillating flow conditions. As the internal pressure or the velocity increases, the vessel buckles, leading to a nonlinear large deformation behaviour. The results have been validated using theoretical predictions for the buckling thresholds and experiments using ex vivo vessels. Further studies on idealised cardiovascular conditions such as stenosis (i.e., lumen constriction) or aneurysm-like (i.e., arterial wall expansion) formation have also been performed as well as calculations on a aortic arch artery whose geometry has been obtained from mice by Synchrotron imaging techniques.
Original languageEnglish
Title of host publicationProceedings of the International Conference on Numerical Analysis and Applied Mathematics 2014 (ICNAAM-2014)
EditorsT E Simos, Ch Tsitouras
Place of PublicationMelville NY USA
PublisherAmerican Institute of Physics
Pages1 - 4
Number of pages4
Volume1648
ISBN (Print)9780735412873
DOIs
Publication statusPublished - 2015
EventInternational Conference on Numerical Analysis and Applied Mathematics (ICNAAM) 2015 - Rodos Palace Hotel, Rhodes, Greece
Duration: 23 Sep 201529 Sep 2015
Conference number: 13th
http://history.icnaam.org/icnaam_2015/index-2.html
http://history.icnaam.org/icnaam_2015/index-2.html

Conference

ConferenceInternational Conference on Numerical Analysis and Applied Mathematics (ICNAAM) 2015
Abbreviated titleICNAAM 2015
CountryGreece
CityRhodes
Period23/09/1529/09/15
Internet address

Cite this

Assemat, P., & Hourigan, K. (2015). Large deformations of elastic vessels under atherosclerotic conditions. In T. E. Simos, & C. Tsitouras (Eds.), Proceedings of the International Conference on Numerical Analysis and Applied Mathematics 2014 (ICNAAM-2014) (Vol. 1648, pp. 1 - 4). Melville NY USA: American Institute of Physics. https://doi.org/10.1063/1.4913142
Assemat, Pauline ; Hourigan, Kerry. / Large deformations of elastic vessels under atherosclerotic conditions. Proceedings of the International Conference on Numerical Analysis and Applied Mathematics 2014 (ICNAAM-2014). editor / T E Simos ; Ch Tsitouras. Vol. 1648 Melville NY USA : American Institute of Physics, 2015. pp. 1 - 4
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title = "Large deformations of elastic vessels under atherosclerotic conditions",
abstract = "Cardiovascular diseases remain the major cause of mortality worldwide. Pathologies of the vasculature such as atherosclerosis are often related to biochemical and genetic factors, as well as mechanical effects that strongly change the function and shape of arteries. The present work is part of a general research project that aims to understand better the mechanical mechanisms responsible for atherosclerotic plaque formation and rupture. The chosen approach is to use numerical fluid structure interaction (FSI) methods to study the relative influence of the hemodynamical stresses and the structural stresses generated on plaques, in combination with an experimental approach to validate the results. To meet this aim, a numerical study of a simplified straight vessel exposed to lumen pressure was investigated under quiescent, steady and oscillating flow conditions. As the internal pressure or the velocity increases, the vessel buckles, leading to a nonlinear large deformation behaviour. The results have been validated using theoretical predictions for the buckling thresholds and experiments using ex vivo vessels. Further studies on idealised cardiovascular conditions such as stenosis (i.e., lumen constriction) or aneurysm-like (i.e., arterial wall expansion) formation have also been performed as well as calculations on a aortic arch artery whose geometry has been obtained from mice by Synchrotron imaging techniques.",
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Assemat, P & Hourigan, K 2015, Large deformations of elastic vessels under atherosclerotic conditions. in TE Simos & C Tsitouras (eds), Proceedings of the International Conference on Numerical Analysis and Applied Mathematics 2014 (ICNAAM-2014). vol. 1648, American Institute of Physics, Melville NY USA, pp. 1 - 4, International Conference on Numerical Analysis and Applied Mathematics (ICNAAM) 2015, Rhodes, Greece, 23/09/15. https://doi.org/10.1063/1.4913142

Large deformations of elastic vessels under atherosclerotic conditions. / Assemat, Pauline; Hourigan, Kerry.

Proceedings of the International Conference on Numerical Analysis and Applied Mathematics 2014 (ICNAAM-2014). ed. / T E Simos; Ch Tsitouras. Vol. 1648 Melville NY USA : American Institute of Physics, 2015. p. 1 - 4.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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Assemat P, Hourigan K. Large deformations of elastic vessels under atherosclerotic conditions. In Simos TE, Tsitouras C, editors, Proceedings of the International Conference on Numerical Analysis and Applied Mathematics 2014 (ICNAAM-2014). Vol. 1648. Melville NY USA: American Institute of Physics. 2015. p. 1 - 4 https://doi.org/10.1063/1.4913142