TY - JOUR
T1 - Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus
AU - Lund, Nicole
AU - Branch, Donald R
AU - Sakac, Darinka
AU - Lingwood, Clifford A
AU - Siatskas, Christopher
AU - Robinson, Chevalia J
AU - Brady, Roscoe O
AU - Medin, Jeff
PY - 2005
Y1 - 2005
N2 - A lack of viral replication after HIV-1Ba-L (R5) but not HIV-1IIIB (X4) infection was found using in-vitro activated peripheral blood-derived mononuclear cells from patients with Fabry disease, who have a defect in the catabolism of globotriaosylceramide. CCR5, but not CD4 or CXCR4 expression levels, were lower and the surface expression of globotriaosylceramide was negligible on activated patients cells. Our findings suggest a novel resistance mechanism to productive infection with R5 HIV-1 that potentially involves abnormal globotriaosylceramide catabolism.
AB - A lack of viral replication after HIV-1Ba-L (R5) but not HIV-1IIIB (X4) infection was found using in-vitro activated peripheral blood-derived mononuclear cells from patients with Fabry disease, who have a defect in the catabolism of globotriaosylceramide. CCR5, but not CD4 or CXCR4 expression levels, were lower and the surface expression of globotriaosylceramide was negligible on activated patients cells. Our findings suggest a novel resistance mechanism to productive infection with R5 HIV-1 that potentially involves abnormal globotriaosylceramide catabolism.
UR - http://www.ncbi.nlm.nih.gov/pubmed/16135910
M3 - Article
SN - 0269-9370
VL - 19
SP - 1543
EP - 1546
JO - AIDS
JF - AIDS
IS - 14
ER -
