Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus

Nicole Lund, Donald R Branch, Darinka Sakac, Clifford A Lingwood, Christopher Siatskas, Chevalia J Robinson, Roscoe O Brady, Jeff Medin

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26 Citations (Scopus)

Abstract

A lack of viral replication after HIV-1Ba-L (R5) but not HIV-1IIIB (X4) infection was found using in-vitro activated peripheral blood-derived mononuclear cells from patients with Fabry disease, who have a defect in the catabolism of globotriaosylceramide. CCR5, but not CD4 or CXCR4 expression levels, were lower and the surface expression of globotriaosylceramide was negligible on activated patients cells. Our findings suggest a novel resistance mechanism to productive infection with R5 HIV-1 that potentially involves abnormal globotriaosylceramide catabolism.
Original languageEnglish
Pages (from-to)1543 - 1546
Number of pages4
JournalAIDS
Volume19
Issue number14
Publication statusPublished - 2005
Externally publishedYes

Cite this

Lund, N., Branch, D. R., Sakac, D., Lingwood, C. A., Siatskas, C., Robinson, C. J., Brady, R. O., & Medin, J. (2005). Lack of susceptibility of cells from patients with Fabry disease to productive infection with R5 human immunodeficiency virus. AIDS, 19(14), 1543 - 1546.