TY - JOUR
T1 - Laboratory evolution of protein conformational dynamics
AU - Campbell, Eleanor C.
AU - Correy, Galen J.
AU - Mabbitt, Peter D.
AU - Buckle, Ashley M
AU - Tokiriki, Nobuhiko
AU - Jackson, Colin J.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.
AB - This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.
UR - http://www.scopus.com/inward/record.url?scp=85032974150&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2017.09.005
DO - 10.1016/j.sbi.2017.09.005
M3 - Review Article
AN - SCOPUS:85032974150
SN - 0959-440X
VL - 50
SP - 49
EP - 57
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -