Labetalol steady‐state pharmacokinetics in hypertensive patients.

JJ McNeil, AE Anderson, WJ Louis, K. Raymond

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1 During chronic treatment of hypertensive patients observed mean steady‐state plasma labetalol levels in ten patients were consistently and significantly higher than predicted from initial acute pharmacokinetic analysis. 2 Mean steady‐state levels varied from 36 to 183 ng/ml on a chronic dose of 200 mg twice daily. 3 Patients with lower steady‐state levels on a fixed dose of labetalol usually required higher maintenance doses to control blood pressure. 1982 The British Pharmacological Society

Original languageEnglish
Pages (from-to)75S-80S
JournalBritish Journal of Clinical Pharmacology
Issue number1 S
Publication statusPublished - 1 Jan 1982

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