Labetalol steady‐state pharmacokinetics in hypertensive patients.

JJ McNeil; AE Anderson; WJ Louis; K. Raymond

doi:10.1111/j.1365-2125.1982.tb01892.x

Labetalol steady‐state pharmacokinetics in hypertensive patients.

JJ McNeil, AE Anderson, WJ Louis, K. Raymond

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

1 During chronic treatment of hypertensive patients observed mean steady‐state plasma labetalol levels in ten patients were consistently and significantly higher than predicted from initial acute pharmacokinetic analysis. 2 Mean steady‐state levels varied from 36 to 183 ng/ml on a chronic dose of 200 mg twice daily. 3 Patients with lower steady‐state levels on a fixed dose of labetalol usually required higher maintenance doses to control blood pressure. 1982 The British Pharmacological Society

Original language	English
Pages (from-to)	75S-80S
Journal	British Journal of Clinical Pharmacology
Volume	13
Issue number	1 S
DOIs	https://doi.org/10.1111/j.1365-2125.1982.tb01892.x
Publication status	Published - 1 Jan 1982

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10.1111/j.1365-2125.1982.tb01892.x

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Cite this

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title = "Labetalol steady‐state pharmacokinetics in hypertensive patients.",

abstract = "1 During chronic treatment of hypertensive patients observed mean steady‐state plasma labetalol levels in ten patients were consistently and significantly higher than predicted from initial acute pharmacokinetic analysis. 2 Mean steady‐state levels varied from 36 to 183 ng/ml on a chronic dose of 200 mg twice daily. 3 Patients with lower steady‐state levels on a fixed dose of labetalol usually required higher maintenance doses to control blood pressure. 1982 The British Pharmacological Society",

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