Label-free Si3N4 photonic crystal based immunosensors for diagnostic applications

D. Zecca, A. Qualtieri, G. Magno, M. Grande, V. Petruzzelli, B. Prieto-Simon, A. D'Orazio, M. De Vittorio, N. H. Voelcker, T. Stomeo

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9 Citations (Scopus)

Abstract

Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm × 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.

Original languageEnglish
Article number6892930
Number of pages7
JournalIEEE Photonics Journal
Volume6
Issue number6
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Keywords

  • biosensors
  • fabrication and characterization
  • Photonic crystals (PhC)

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