KLF1 directly coordinates almost all aspects of terminal erythroid differentiation

Michael R. Tallack, Andrew C. Perkins

Research output: Contribution to journalReview ArticleResearchpeer-review

50 Citations (Scopus)

Abstract

The molecular events and transcriptional mechanisms that underlie erythropoiesis are of great interest to biologists and hematologists since disorders of erythrocytes are common and remain relatively poorly understood. Kruppel-like factor 1 (KLF1) is a critical transcription factor for erythropoiesis in mice and man. Recently the use of chromatin immunoprecipitation (ChIP) coupled to next-generation DNA sequencing (ChIP-seq) has led to an updated understanding of how KLF1 functions in vivo. The full extent of KLF1 target genes have provided new insights into erythropoiesis, and have established that KLF1 controls almost all aspects of erythroid cell development and maturation.

Original languageEnglish
Pages (from-to)886-890
Number of pages5
JournalIUBMB Life
Volume62
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • apoptosis
  • erythrocytes
  • hemoglobin
  • iron
  • thalassemia
  • transcription factors
  • transcriptional regulation

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