Abstract
Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public health problem. While resistance can occur across a broad range of Kp clones, a small number have become globally distributed and commonly cause outbreaks in hospital settings. Here we describe recent comparative genomics investigations that have shed light on Kp population structure and the evolution of antimicrobial-resistant clones. These studies provide the basic framework within which genomic epidemiology and evolution can be understood, but have merely scratched the surface of what can and should be explored. We assert that further large-scale comparative and functional genomics studies are urgently needed to better understand the biology of this clinically important bacterium.
| Original language | English |
|---|---|
| Pages (from-to) | 944-956 |
| Number of pages | 13 |
| Journal | Trends in Microbiology |
| Volume | 24 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2016 |
| Externally published | Yes |
Keywords
- antimicrobial resistance
- genomics
- Klebsiella pneumoniae
- population structure
Cite this
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Klebsiella pneumoniae Population Genomics and Antimicrobial-Resistant Clones. / Wyres, Kelly L.; Holt, Kathryn E.
In: Trends in Microbiology, Vol. 24, No. 12, 01.12.2016, p. 944-956.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Klebsiella pneumoniae Population Genomics and Antimicrobial-Resistant Clones
AU - Wyres, Kelly L.
AU - Holt, Kathryn E.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public health problem. While resistance can occur across a broad range of Kp clones, a small number have become globally distributed and commonly cause outbreaks in hospital settings. Here we describe recent comparative genomics investigations that have shed light on Kp population structure and the evolution of antimicrobial-resistant clones. These studies provide the basic framework within which genomic epidemiology and evolution can be understood, but have merely scratched the surface of what can and should be explored. We assert that further large-scale comparative and functional genomics studies are urgently needed to better understand the biology of this clinically important bacterium.
AB - Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public health problem. While resistance can occur across a broad range of Kp clones, a small number have become globally distributed and commonly cause outbreaks in hospital settings. Here we describe recent comparative genomics investigations that have shed light on Kp population structure and the evolution of antimicrobial-resistant clones. These studies provide the basic framework within which genomic epidemiology and evolution can be understood, but have merely scratched the surface of what can and should be explored. We assert that further large-scale comparative and functional genomics studies are urgently needed to better understand the biology of this clinically important bacterium.
KW - antimicrobial resistance
KW - genomics
KW - Klebsiella pneumoniae
KW - population structure
UR - http://www.scopus.com/inward/record.url?scp=84997190990&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2016.09.007
DO - 10.1016/j.tim.2016.09.007
M3 - Review Article
VL - 24
SP - 944
EP - 956
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 12
ER -