TY - JOUR
T1 - Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria
AU - Wyres, Kelly L.
AU - Holt, Kathryn E.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae's contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.
AB - Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae's contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.
UR - http://www.scopus.com/inward/record.url?scp=85046169134&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2018.04.004
DO - 10.1016/j.mib.2018.04.004
M3 - Review Article
C2 - 29723841
AN - SCOPUS:85046169134
SN - 1369-5274
VL - 45
SP - 131
EP - 139
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -
