KinetochoreDB: a comprehensive online resource for the kinetochore and its related proteins

Chen Li, Steve G Androulakis, Ashley M Buckle, Jiangning Song

Research output: Contribution to journalArticleResearchpeer-review

Abstract

KinetochoreDB is an online resource for the kinetochore and its related proteins. It provides comprehensive annotations on 1554 related protein entries in terms of their amino acid sequence, protein domain context, protein 3D structure, predicted intrinsically disordered region, protein-protein interaction, post-translational modification site, functional domain and key metabolic/signaling pathways, integrating several public databases, computational annotations and experimental results. KinetochoreDB provides interactive and customizable search and data display functions that allow users to interrogate the database in an efficient and user-friendly manner. It uses PSI-BLAST searches to retrieve the homologs of all entries and generate multiple sequence alignments that contain important evolutionary information. This knowledgebase also provides annotations of single point mutations for entries with respect to their pathogenicity, which may be useful for generation of new hypotheses on their functions, as well as follow-up studies of human diseases.Database URL: http://lightning.med.monash.edu/kinetochoreDB2/.
Original languageEnglish
Article numberbaw019
Number of pages10
JournalDatabase: the Journal of Biological Databases and Curation
Volume2016
DOIs
Publication statusPublished - 2016

Cite this

@article{b01bd11f24cf400f925b37299ae43cda,
title = "KinetochoreDB: a comprehensive online resource for the kinetochore and its related proteins",
abstract = "KinetochoreDB is an online resource for the kinetochore and its related proteins. It provides comprehensive annotations on 1554 related protein entries in terms of their amino acid sequence, protein domain context, protein 3D structure, predicted intrinsically disordered region, protein-protein interaction, post-translational modification site, functional domain and key metabolic/signaling pathways, integrating several public databases, computational annotations and experimental results. KinetochoreDB provides interactive and customizable search and data display functions that allow users to interrogate the database in an efficient and user-friendly manner. It uses PSI-BLAST searches to retrieve the homologs of all entries and generate multiple sequence alignments that contain important evolutionary information. This knowledgebase also provides annotations of single point mutations for entries with respect to their pathogenicity, which may be useful for generation of new hypotheses on their functions, as well as follow-up studies of human diseases.Database URL: http://lightning.med.monash.edu/kinetochoreDB2/.",
author = "Chen Li and Androulakis, {Steve G} and Buckle, {Ashley M} and Jiangning Song",
year = "2016",
doi = "10.1093/database/baw019",
language = "English",
volume = "2016",
journal = "Database: the Journal of Biological Databases and Curation",
issn = "1758-0463",
publisher = "Oxford University Press",

}

KinetochoreDB: a comprehensive online resource for the kinetochore and its related proteins. / Li, Chen; Androulakis, Steve G; Buckle, Ashley M; Song, Jiangning.

In: Database: the Journal of Biological Databases and Curation, Vol. 2016, baw019, 2016.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - KinetochoreDB: a comprehensive online resource for the kinetochore and its related proteins

AU - Li, Chen

AU - Androulakis, Steve G

AU - Buckle, Ashley M

AU - Song, Jiangning

PY - 2016

Y1 - 2016

N2 - KinetochoreDB is an online resource for the kinetochore and its related proteins. It provides comprehensive annotations on 1554 related protein entries in terms of their amino acid sequence, protein domain context, protein 3D structure, predicted intrinsically disordered region, protein-protein interaction, post-translational modification site, functional domain and key metabolic/signaling pathways, integrating several public databases, computational annotations and experimental results. KinetochoreDB provides interactive and customizable search and data display functions that allow users to interrogate the database in an efficient and user-friendly manner. It uses PSI-BLAST searches to retrieve the homologs of all entries and generate multiple sequence alignments that contain important evolutionary information. This knowledgebase also provides annotations of single point mutations for entries with respect to their pathogenicity, which may be useful for generation of new hypotheses on their functions, as well as follow-up studies of human diseases.Database URL: http://lightning.med.monash.edu/kinetochoreDB2/.

AB - KinetochoreDB is an online resource for the kinetochore and its related proteins. It provides comprehensive annotations on 1554 related protein entries in terms of their amino acid sequence, protein domain context, protein 3D structure, predicted intrinsically disordered region, protein-protein interaction, post-translational modification site, functional domain and key metabolic/signaling pathways, integrating several public databases, computational annotations and experimental results. KinetochoreDB provides interactive and customizable search and data display functions that allow users to interrogate the database in an efficient and user-friendly manner. It uses PSI-BLAST searches to retrieve the homologs of all entries and generate multiple sequence alignments that contain important evolutionary information. This knowledgebase also provides annotations of single point mutations for entries with respect to their pathogenicity, which may be useful for generation of new hypotheses on their functions, as well as follow-up studies of human diseases.Database URL: http://lightning.med.monash.edu/kinetochoreDB2/.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26989151

U2 - 10.1093/database/baw019

DO - 10.1093/database/baw019

M3 - Article

VL - 2016

JO - Database: the Journal of Biological Databases and Curation

JF - Database: the Journal of Biological Databases and Curation

SN - 1758-0463

M1 - baw019

ER -