Kinetic dependence of paramyxovirus entry inhibition

Matteo Porotto, Christine Yokojama, Gianmarco Orefice, Han-Sung Kim, Mohamad Aljofan, Bruce Mungall, Anne Moscona

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26 Citations (Scopus)


Peptides derived from conserved heptad repeat (HR) regions of paramyxovirus fusion (F) proteins inhibit viral fusion by interfering with the formation of the fusogenic six-helix bundle structure. Peptide efficacy is affected by the strength of the peptide association with the target virus s complementary HR region. Here, we show that a second basis for peptide efficacy lies in the kinetics of F activation by the homotypic attachment protein: efficient F activation by the attachment protein shortens the period during which antiviral molecules targeting intermediate states of F may act, thereby modulating the effectiveness of inhibitory peptides. These results highlight new issues to be considered in developing strategies for fusion inhibitors.
Original languageEnglish
Pages (from-to)6947 - 6951
Number of pages5
JournalJournal of Virology
Issue number13
Publication statusPublished - 2009

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