Killers and beyond: NK-cell-mediated control of immune responses

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Effective immunity requires coordinated activation of innate and adaptive immune responses. NK cells are principal mediators of innate immunity, able to respond to challenge quickly and generally without prior activation. The most acknowledged functions of NK cells are their cytotoxic potential and their ability to release large amounts of cytokines, especially IFN-γ. Recently, it has become clear that NK cells are more than assassins. Indeed, NK cells play critical roles in shaping adaptive immunity.

Original languageEnglish
Pages (from-to)2938-2942
Number of pages5
JournalEuropean Journal of Immunology
Issue number11
Publication statusPublished - 1 Dec 2008


  • Cellular immunology
  • Cytokines
  • NK cells

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