Killer T cells in influenza

John Stambas, Carole Guillonneau, Katherine Kedzierska, Justine D. Mintern, Peter C. Doherty, Nicole L. La Gruta

Research output: Contribution to journalReview ArticleResearchpeer-review

33 Citations (Scopus)

Abstract

Antigen-specific CD8+ T cells play an important role in virus clearance. Here we review the current understanding of influenza virus-specific CD8+ T cell immunity in experimental mouse models and humans. The characteristics and nature of CD8+ T cell killing are discussed, as is the selection and maintenance of the influenza-specific effector and memory repertoires. Consideration is given to vaccine strategies and to the effects of ageing. Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses.

Original languageEnglish
Pages (from-to)186-196
Number of pages11
JournalPharmacology and Therapeutics
Volume120
Issue number2
DOIs
Publication statusPublished - 1 Nov 2008

Keywords

  • Ageing
  • CD8+ T cells
  • Cytotoxicity
  • Influenza
  • Memory
  • TCR repertoire
  • Vaccine

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