Ketogenic diet intervention for the treatment of epilepsy via gut microbiome modulation

A ketogenic diet (KD) - a high fat (90% of calories), moderate protein, and low carbohydrate dietary regimen has been extensively as an epilepsy treatment prior to the advent of antiepileptic drugs. Emerging evidence highlights the microbiota-gut-brain axis as a critical mediator between gut microbiome composition and neurological disorders, including epilepsy. Dietary interventions represent one of the most significant modifiable factors influencing gut microbiome composition, in which the intestinal microbial community could influence neurotransmission in the central nervous system in a bidirectional manner. Thus, this research aims to investigate the anti-seizure effects of KD and its impact on gut microbiome modulation.