TY - JOUR
T1 - Keeping the host alive - Lessons from obligate intracellular bacterial pathogens
AU - Loterio, Robson Kriiger
AU - Zamboni, Dario S.
AU - Newton, Hayley J.
N1 - Funding Information:
RKL is funded by the postgraduate program of basic and applied immunology from the Medical School of Ribeir ˜ao Preto, University of S˜ao Paulo, Brazil. Research in the DSZ laboratory is funded by grants from FAPESP (2014/04684–4, 2016/24275–7 and 2019/11342–6).
Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2021/12
Y1 - 2021/12
N2 - Mammals have evolved sophisticated host cell death signaling pathways as an important immune mechanism to recognize and eliminate cell intruders before they establish their replicative niche. However, intracellular bacterial pathogens that have co-evolved with their host have developed a multitude of tactics to counteract this defense strategy to facilitate their survival and replication. This requires manipulation of pro-death and pro-survival host signaling pathways during infection. Obligate intracellular bacterial pathogens are organisms that absolutely require an eukaryotic host to survive and replicate, and therefore they have developed virulence factors to prevent diverse forms of host cell death and conserve their replicative niche. This review encapsulates our current understanding of these host-pathogen interactions by exploring the most relevant findings of Anaplasma spp., Chlamydia spp., Rickettsia spp. and Coxiella burnetii modulating host cell death pathways. A detailed comprehension of the molecular mechanisms through which these obligate intracellular pathogens manipulate regulated host cell death will not only increase the current understanding of these difficult-to-study pathogens but also provide insights into new tools to study regulated cell death and the development of new therapeutic approaches to control infection.
AB - Mammals have evolved sophisticated host cell death signaling pathways as an important immune mechanism to recognize and eliminate cell intruders before they establish their replicative niche. However, intracellular bacterial pathogens that have co-evolved with their host have developed a multitude of tactics to counteract this defense strategy to facilitate their survival and replication. This requires manipulation of pro-death and pro-survival host signaling pathways during infection. Obligate intracellular bacterial pathogens are organisms that absolutely require an eukaryotic host to survive and replicate, and therefore they have developed virulence factors to prevent diverse forms of host cell death and conserve their replicative niche. This review encapsulates our current understanding of these host-pathogen interactions by exploring the most relevant findings of Anaplasma spp., Chlamydia spp., Rickettsia spp. and Coxiella burnetii modulating host cell death pathways. A detailed comprehension of the molecular mechanisms through which these obligate intracellular pathogens manipulate regulated host cell death will not only increase the current understanding of these difficult-to-study pathogens but also provide insights into new tools to study regulated cell death and the development of new therapeutic approaches to control infection.
KW - anaplasma
KW - Chlamydia
KW - Coxiella burnetii
KW - obligate intracellular bacterial pathogen
KW - regulated cell death
KW - rickettsia
UR - http://www.scopus.com/inward/record.url?scp=85122546569&partnerID=8YFLogxK
U2 - 10.1093/femspd/ftab052
DO - 10.1093/femspd/ftab052
M3 - Review Article
C2 - 34755855
AN - SCOPUS:85122546569
SN - 2049-632X
VL - 79
JO - Pathogens and Disease
JF - Pathogens and Disease
IS - 9
M1 - ftab052
ER -