Projects per year
Abstract
Naive CD8+ T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanisms that underpin this process are unclear. Here, we profile genome-wide changes in chromatin accessibility, gene transcription, and the deposition of a key chromatin modification (H3K27me3) early after naive CD8+ T cell activation. Rapid upregulation of the histone demethylase KDM6B prior to the first cell division is required for initiating H3K27me3 removal at genes essential for subsequent T cell differentiation and proliferation. Inhibition of KDM6B-dependent H3K27me3 demethylation limits the magnitude of an effective primary virus-specific CD8+ T cell response and the formation of memory CD8+ T cell populations. Accordingly, we define the early spatiotemporal events underpinning early lineage-specific chromatin reprogramming that are necessary for autonomous CD8+ T cell proliferation and differentiation.
Original language | English |
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Article number | 108839 |
Number of pages | 21 |
Journal | Cell Reports |
Volume | 34 |
Issue number | 11 |
DOIs | |
Publication status | Published - 16 Mar 2021 |
Keywords
- CD8 T cell
- chromatin
- histone demethylase
- T cell activation
- T cell memory
- virus immunity
Projects
- 1 Finished
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Determining how enhancers regulate T cell differentiation and function
Turner, S. & Rao, S.
Australian Research Council (ARC), Monash University – Internal Faculty Contribution, University of Canberra
1/01/17 → 31/12/20
Project: Research