Kawasaki disease and cardiovascular risk: A comprehensive review of subclinical vascular changes in the longer term

Katherine Y H Chen, Nigel Curtis, Nagib Dahdah, Remi R. Kowalski, Michael M H Cheung, David P. Burgner

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Studies of subclinical vascular changes post-Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima-media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened cardiovascular risk. The results are less consistent for low-risk groups. Conclusion Until data are available from larger prospective studies, it is prudent to advise families of individuals with a history of Kawasaki disease to minimise traditional modifiable cardiovascular risk factors.

Original languageEnglish
Pages (from-to)752-761
Number of pages10
JournalActa Paediatrica
Volume105
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • Carotid intima-media thickness
  • Endothelial function
  • Kawasaki disease
  • Mucocutaneous lymph node syndrome
  • Vascular stiffness

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