TY - JOUR
T1 - Kappa-carrageenan/halloysite nanocomposite hydrogels as potential drug delivery systems
AU - Sharifzadeh, Ghorbanali
AU - Wahit, Mat Uzir
AU - Soheilmoghaddam, Mohammad
AU - Whye, Wong Tuck
AU - Pasbakhsh, Pooria
N1 - Funding Information:
The authors wish to acknowledge Fundamental Research Grant Scheme (FRGS) Vote no: R.J130000.7809.4F546 by Universiti Teknologi Malaysia from the Ministry of Education Malaysia.
Publisher Copyright:
© 2016 Taiwan Institute of Chemical Engineers
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/10
Y1 - 2016/10
N2 - Novel kappa-carrageenan (Kc)/halloysite nanotube (HNT) nanocomposite hydrogels were synthesized via physical crosslinking for the gastro-intestinal tract (GIT) release. The influence of HNT nanoparticle content on Kc/HNT hydrogel properties such as thermal, swelling, drug loading and in vitro release was examined. Thermal results revealed that the incorporation of HNT nanoparticles enhanced the thermal stability of the nanocomposite hydrogels. Also, the nanocomposite hydrogels showed higher swelling, drug loading and release behavior compared to the pure Kc hydrogel. In vitro release from the Kc-HNT hydrogels exhibited that rhodamine B (RB), a cationic model drug, released higher than orange G (OG), an anionic model drug. RB in vitro release from the nanocomposite hydrogels reached to approximately 72%, while 54% of OG was released. Finally, in vitro cytotoxicity test revealed that both Kc and Kc-HNT hydrogels are biocompatible. Taking together, it was shown that Kc-HNT hydrogels may have a great potential applications in oral drug delivery systems.
AB - Novel kappa-carrageenan (Kc)/halloysite nanotube (HNT) nanocomposite hydrogels were synthesized via physical crosslinking for the gastro-intestinal tract (GIT) release. The influence of HNT nanoparticle content on Kc/HNT hydrogel properties such as thermal, swelling, drug loading and in vitro release was examined. Thermal results revealed that the incorporation of HNT nanoparticles enhanced the thermal stability of the nanocomposite hydrogels. Also, the nanocomposite hydrogels showed higher swelling, drug loading and release behavior compared to the pure Kc hydrogel. In vitro release from the Kc-HNT hydrogels exhibited that rhodamine B (RB), a cationic model drug, released higher than orange G (OG), an anionic model drug. RB in vitro release from the nanocomposite hydrogels reached to approximately 72%, while 54% of OG was released. Finally, in vitro cytotoxicity test revealed that both Kc and Kc-HNT hydrogels are biocompatible. Taking together, it was shown that Kc-HNT hydrogels may have a great potential applications in oral drug delivery systems.
KW - Halloysite nanotube
KW - Hydrogels
KW - In vitro drug release
KW - Kappa-carrageenan
KW - Nanocomposites
UR - https://www.scopus.com/pages/publications/84997795124
U2 - 10.1016/j.jtice.2016.07.027
DO - 10.1016/j.jtice.2016.07.027
M3 - Article
AN - SCOPUS:84997795124
SN - 1876-1070
VL - 67
SP - 426
EP - 434
JO - Journal of the Taiwan Institute of Chemical Engineers
JF - Journal of the Taiwan Institute of Chemical Engineers
ER -