Kappa-carrageenan/halloysite nanocomposite hydrogels as potential drug delivery systems

Ghorbanali Sharifzadeh, Mat Uzir Wahit, Mohammad Soheilmoghaddam, Wong Tuck Whye, Pooria Pasbakhsh

    Research output: Contribution to journalArticleResearchpeer-review

    25 Citations (Scopus)

    Abstract

    Novel kappa-carrageenan (Kc)/halloysite nanotube (HNT) nanocomposite hydrogels were synthesized via physical crosslinking for the gastro-intestinal tract (GIT) release. The influence of HNT nanoparticle content on Kc/HNT hydrogel properties such as thermal, swelling, drug loading and in vitro release was examined. Thermal results revealed that the incorporation of HNT nanoparticles enhanced the thermal stability of the nanocomposite hydrogels. Also, the nanocomposite hydrogels showed higher swelling, drug loading and release behavior compared to the pure Kc hydrogel. In vitro release from the Kc-HNT hydrogels exhibited that rhodamine B (RB), a cationic model drug, released higher than orange G (OG), an anionic model drug. RB in vitro release from the nanocomposite hydrogels reached to approximately 72%, while 54% of OG was released. Finally, in vitro cytotoxicity test revealed that both Kc and Kc-HNT hydrogels are biocompatible. Taking together, it was shown that Kc-HNT hydrogels may have a great potential applications in oral drug delivery systems.

    Original languageEnglish
    Pages (from-to)426-434
    Number of pages9
    JournalJournal of the Taiwan Institute of Chemical Engineers
    Volume67
    DOIs
    Publication statusPublished - Oct 2016

    Keywords

    • Halloysite nanotube
    • Hydrogels
    • In vitro drug release
    • Kappa-carrageenan
    • Nanocomposites

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