Journey towards a personalised medicine approach for OSA: Can a similar approach to adult OSA be applied to paediatric OSA?

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Abstract

The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition show a similar level of heterogeneity and paediatric obstructive sleep apnoea would also benefit from a more targeted approach to diagnosis and management. This review aims to summarise the adult literature on the phenotypes and endotypes of obstructive sleep apnoea and assess whether a similar approach may also be suitable to guide the development of new diagnostic and management approaches for paediatric obstructive sleep apnoea.

Original languageEnglish
Pages (from-to)128-135
Number of pages8
JournalPaediatric Respiratory Reviews
Volume36
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Obstructive sleep apnoea
  • Personalised medicine
  • Phenotyping
  • Sleep
  • Sleep disordered breathing

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