Journey towards a personalised medicine approach for OSA: Can a similar approach to adult OSA be applied to paediatric OSA?

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Abstract

The concept of personalised medicine is likely to revolutionise the treatment of adult obstructive sleep apnoea as a result of recent advances in the understanding of disease heterogeneity by identifying clinical phenotypes, pathophysiological endotypes, biomarkers and treatable traits. Children with the condition show a similar level of heterogeneity and paediatric obstructive sleep apnoea would also benefit from a more targeted approach to diagnosis and management. This review aims to summarise the adult literature on the phenotypes and endotypes of obstructive sleep apnoea and assess whether a similar approach may also be suitable to guide the development of new diagnostic and management approaches for paediatric obstructive sleep apnoea.

Original languageEnglish
Number of pages8
JournalPaediatric Respiratory Reviews
DOIs
Publication statusAccepted/In press - 14 Feb 2020

Keywords

  • Obstructive sleep apnoea
  • Personalised medicine
  • Phenotyping
  • Sleep
  • Sleep disordered breathing

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