TY - JOUR
T1 - Joint associations of smoking and television viewing time on cancer and cardiovascular disease mortality
AU - Grace, Megan S.
AU - Lynch, Brigid M.
AU - Dillon, Francis
AU - Barr, Elizabeth L.M.
AU - Owen, Neville
AU - Dunstan, David W.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Excessive sitting time and smoking are pro-inflammatory lifestyle factors that are associated with both cancer and cardiovascular disease (CVD) mortality. However, their joint associations have not been investigated. We examined the associations of television (TV) viewing time with cancer and CVD mortality, according to smoking status, among 7,498 non-smokers (34% ex-smokers) and 1,409 current-smokers in the Australian Diabetes, Obesity and Lifestyle Study. During 117,506 person-years (median 13.6 years) of follow-up, there were 346 cancer and 209 CVD-related deaths. Including an interaction between TV time and smoking status in the model significantly improved the goodness of fit for cancer (p = 0.01) but not CVD mortality (p = 0.053). In the multivariate-adjusted model, every additional hr/d of TV time was associated with increased risk of cancer-related (HR 1.23; 95% CI 1.08–1.40), but not CVD-related mortality (HR 1.16; 95% CI 0.97–1.38) in current-smokers. Elevated multivariate-adjusted cancer mortality HRs were observed for current-smokers watching 2 to <4 hr/d (HR 1.45; 95% CI 0.78–2.71) and ≥4 hr/d (HR 2.26; 95% CI 1.10–4.64), compared to those watching <2 hr/d. Current-smokers watching 2 to <4 hr/d (HR 1.07; 95% CI 0.45–2.53) and ≥4 hr/d (HR 1.92; 95% CI 0.76–4.84) did not have a significantly higher risk of CVD mortality, compared to <2 hr/d. No associations were observed for non-smokers. These findings show an association of TV, a common sedentary behavior, with cancer mortality in current-smokers. The association with CVD mortality was less clear. Further exploration in larger data sets is warranted. Limiting TV viewing time may be of benefit in reducing cancer mortality risk in current-smokers.
AB - Excessive sitting time and smoking are pro-inflammatory lifestyle factors that are associated with both cancer and cardiovascular disease (CVD) mortality. However, their joint associations have not been investigated. We examined the associations of television (TV) viewing time with cancer and CVD mortality, according to smoking status, among 7,498 non-smokers (34% ex-smokers) and 1,409 current-smokers in the Australian Diabetes, Obesity and Lifestyle Study. During 117,506 person-years (median 13.6 years) of follow-up, there were 346 cancer and 209 CVD-related deaths. Including an interaction between TV time and smoking status in the model significantly improved the goodness of fit for cancer (p = 0.01) but not CVD mortality (p = 0.053). In the multivariate-adjusted model, every additional hr/d of TV time was associated with increased risk of cancer-related (HR 1.23; 95% CI 1.08–1.40), but not CVD-related mortality (HR 1.16; 95% CI 0.97–1.38) in current-smokers. Elevated multivariate-adjusted cancer mortality HRs were observed for current-smokers watching 2 to <4 hr/d (HR 1.45; 95% CI 0.78–2.71) and ≥4 hr/d (HR 2.26; 95% CI 1.10–4.64), compared to those watching <2 hr/d. Current-smokers watching 2 to <4 hr/d (HR 1.07; 95% CI 0.45–2.53) and ≥4 hr/d (HR 1.92; 95% CI 0.76–4.84) did not have a significantly higher risk of CVD mortality, compared to <2 hr/d. No associations were observed for non-smokers. These findings show an association of TV, a common sedentary behavior, with cancer mortality in current-smokers. The association with CVD mortality was less clear. Further exploration in larger data sets is warranted. Limiting TV viewing time may be of benefit in reducing cancer mortality risk in current-smokers.
KW - cancer
KW - cardiovascular disease
KW - sedentary behavior
KW - smoking
KW - television viewing
UR - http://www.scopus.com/inward/record.url?scp=85008449815&partnerID=8YFLogxK
U2 - 10.1002/ijc.30580
DO - 10.1002/ijc.30580
M3 - Article
C2 - 28006837
AN - SCOPUS:85008449815
SN - 0020-7136
VL - 140
SP - 1538
EP - 1544
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 7
ER -