Itle: An open-source device for measuring food intake and operant behavior in rodent home-cages

Bridget A. Matikainen-Ankney, Thomas Earnest, Mohamed Ali, Eric Casey, Justin G. Wang, Amy K. Sutton, Alex A. Legaria, Kia M. Barclay, Laura B. Murdaugh, Makenzie R. Norris, Yu Hsuan Chang, Katrina P. Nguyen, Eric Lin, Alex Reichenbach, Rachel E. Clarke, Romana Stark, Sineadh M. Conway, Filipe Carvalho, Ream Al-Hasani, Jordan G. McCallMeaghan C. Creed, Victor Cazares, Matthew W. Buczynski, Michael J. Krashes, Zane B. Andrews, Alexxai V. Kravitz

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)


Feeding is critical for survival and disruption in the mechanisms that govern food intake underlie disorders such as obesity and anorexia nervosa. It is important to understand both food intake and food motivation to reveal mechanisms underlying feeding disorders. Operant behavioral testing can be used to measure the motivational component to feeding, but most food intake monitoring systems do not measure operant behavior. Here, we present a new solution for monitoring both food intake and motivation in rodent home-cages: The Feeding Experimentation Device version 3 (FED3). FED3 measures food intake and operant behavior in rodent home-cages, enabling longitudinal studies of feeding behavior with minimal experimenter intervention. It has a programmable output for synchronizing behavior with optogenetic stimulation or neural recordings. Finally, FED3 design files are open-source and freely available, allowing researchers to modify FED3 to suit their needs.

Original languageEnglish
Article numbere66173
Number of pages18
Publication statusPublished - Mar 2021

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