Isolation of opiate receptor ligands in coffee

Kenneth N. Wynne, Mary Famüari, Jaroslav H. Boublik, Olaf H. Drummer, Ian D. Rae, John W. Funder

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24 Citations (Scopus)

Abstract

1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor‐active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD‐2, flash chromatography and gel permeation chromatography. 3. Examination of the final concentrate by GC‐MS showed the presence of a number of isomeric (iso)feruloylquinic acid lactones. 4. It is suggested that the synthesis and biological testing of each quinide isomer will establish which is responsible for the opiate receptor activity of instant coffee.

Original languageEnglish
Pages (from-to)785-790
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 1987

Keywords

  • cinnamates
  • coffee
  • narcotic antagonists
  • receptors.

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