Isolation of opiate receptor ligands in coffee

Kenneth N. Wynne; Mary Famüari; Jaroslav H. Boublik; Olaf H. Drummer; Ian D. Rae; John W. Funder

doi:10.1111/j.1440-1681.1987.tb01869.x

Isolation of opiate receptor ligands in coffee

Kenneth N. Wynne, Mary Famüari, Jaroslav H. Boublik, Olaf H. Drummer, Ian D. Rae, John W. Funder

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor‐active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD‐2, flash chromatography and gel permeation chromatography. 3. Examination of the final concentrate by GC‐MS showed the presence of a number of isomeric (iso)feruloylquinic acid lactones. 4. It is suggested that the synthesis and biological testing of each quinide isomer will establish which is responsible for the opiate receptor activity of instant coffee.

Original language	English
Pages (from-to)	785-790
Number of pages	6
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1111/j.1440-1681.1987.tb01869.x
Publication status	Published - Oct 1987

Keywords

cinnamates
coffee
narcotic antagonists
receptors.

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10.1111/j.1440-1681.1987.tb01869.x

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AU - Funder, John W.

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AB - 1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor‐active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD‐2, flash chromatography and gel permeation chromatography. 3. Examination of the final concentrate by GC‐MS showed the presence of a number of isomeric (iso)feruloylquinic acid lactones. 4. It is suggested that the synthesis and biological testing of each quinide isomer will establish which is responsible for the opiate receptor activity of instant coffee.

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Isolation of opiate receptor ligands in coffee

Abstract

Keywords

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