Isolation, characterization and the multi-lineage differentiation potential of rabbit bone marrow-derived mesenchymal stem cells

Sik-Loo Tan, Tunku Sara Ahmad, Lakshmi Selvaratnam, Tunku Kamarul

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    74 Citations (Scopus)

    Abstract

    Mesenchymal stem cells (MSCs) are recognized by their plastic adherent ability, fibroblastic-like appearance, expression of specific surface protein markers, and are defined by their ability to undergo multi-lineage differentiation. Although rabbit bone marrow-derived MSCs (rbMSCs) have been used extensively in previous studies especially in translational research, these cells have neither been defined morphologically and ultrastructurally, nor been compared with their counterparts in humans in their multi-lineage differentiation ability. A study was therefore conducted to define the morphology, surface marker proteins, ultrastructure and multi-lineage differentiation ability of rbMSCs.
    Original languageEnglish
    Pages (from-to)437 - 450
    Number of pages14
    JournalJournal of Anatomy
    Volume222
    Issue number4
    DOIs
    Publication statusPublished - 2013

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