Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids

Ross L. Coppel; Alan F. Cowman; Klaus R. Lingelbach; Graham V. Brown; Robert B. Saint; David J. Kemp; Robin F. Anders

doi:10.1038/306751a0

Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids

Ross L. Coppel, Alan F. Cowman, Klaus R. Lingelbach, Graham V. Brown, Robert B. Saint, David J. Kemp, Robin F. Anders

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.

Original language	English
Pages (from-to)	751-756
Number of pages	6
Journal	Nature
Volume	306
Issue number	5945
DOIs	https://doi.org/10.1038/306751a0
Publication status	Published - 1 Dec 1983
Externally published	Yes

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title = "Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids",

abstract = "Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.",

author = "Coppel, \{Ross L.\} and Cowman, \{Alan F.\} and Lingelbach, \{Klaus R.\} and Brown, \{Graham V.\} and Saint, \{Robert B.\} and Kemp, \{David J.\} and Anders, \{Robin F.\}",

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T1 - Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids

AU - Coppel, Ross L.

AU - Cowman, Alan F.

AU - Lingelbach, Klaus R.

AU - Brown, Graham V.

AU - Saint, Robert B.

AU - Kemp, David J.

AU - Anders, Robin F.

PY - 1983/12/1

Y1 - 1983/12/1

N2 - Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.

AB - Antibodies raised against a Plasmodium falciparum protein expressed in Escherichia coli reacted with a 220,000-molecular weight antigen of mature blood-stage parasites. The protein resembles the sporozoite surface antigen being composed of tandem repeats of 11 amino acids. However, it is isolate-specific and the encoding gene is not detectable in strains that do not express the protein.

UR - https://www.scopus.com/pages/publications/0021054262

U2 - 10.1038/306751a0

DO - 10.1038/306751a0

M3 - Article

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AN - SCOPUS:0021054262

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VL - 306

SP - 751

EP - 756

JO - Nature

JF - Nature

IS - 5945

ER -

Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids

Abstract

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