Isoform-specific bias of histamine H3 receptor agonists

Darren Riddy, Anna Evelyn Cook, Natalie Diepenhorst, Sanja Bosnyak, Ryan Brady, Clotilde Mannoury La Cour, Elisabeth Mocaer, Roger Summers, William Charman, Patrick Michael Sexton, Arthur Christopoulos, Christopher Langmead

Research output: Contribution to conferencePosterOtherpeer-review

Abstract

The histamine H3 receptor (H3R) is widely expressed in human brain and has been implicated in various pathologies, including Alzheimer’s disease, schizophrenia, dementia and Parkinson’s disease. The H3R is subject to extensive gene splicing that gives rise to a large number of functional and non-functional isoforms. G protein-coupled receptors (GPCRs) can adopt different ligand-induced conformations that give rise to biased signalling, however, this has not been studied for the H3R; furthermore, it is unknown whether splice variants of the same receptor engender the same or differential biased signalling.
Original languageEnglish
Publication statusPublished - 2016
EventASCEPT-MPGPCR Joint Scientific Meeting 2016: Therapeutic targeting: right place, right time, right effect - Melbourne Convention & Exhibition Centre, Melbourne, Australia
Duration: 27 Nov 201630 Nov 2016
https://www.asceptasm.com/2016-annual-scientific-meeting/program-workshops/

Conference

ConferenceASCEPT-MPGPCR Joint Scientific Meeting 2016
Abbreviated titleASCEPT/MPGPCR 2016
CountryAustralia
CityMelbourne
Period27/11/1630/11/16
Internet address

Cite this

Riddy, D., Cook, A. E., Diepenhorst, N., Bosnyak, S., Brady, R., La Cour, C. M., ... Langmead, C. (2016). Isoform-specific bias of histamine H3 receptor agonists. Poster session presented at ASCEPT-MPGPCR Joint Scientific Meeting 2016, Melbourne, Australia.
Riddy, Darren ; Cook, Anna Evelyn ; Diepenhorst, Natalie ; Bosnyak, Sanja ; Brady, Ryan ; La Cour, Clotilde Mannoury ; Mocaer, Elisabeth ; Summers, Roger ; Charman, William ; Sexton, Patrick Michael ; Christopoulos, Arthur ; Langmead, Christopher. / Isoform-specific bias of histamine H3 receptor agonists. Poster session presented at ASCEPT-MPGPCR Joint Scientific Meeting 2016, Melbourne, Australia.
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title = "Isoform-specific bias of histamine H3 receptor agonists",
abstract = "The histamine H3 receptor (H3R) is widely expressed in human brain and has been implicated in various pathologies, including Alzheimer’s disease, schizophrenia, dementia and Parkinson’s disease. The H3R is subject to extensive gene splicing that gives rise to a large number of functional and non-functional isoforms. G protein-coupled receptors (GPCRs) can adopt different ligand-induced conformations that give rise to biased signalling, however, this has not been studied for the H3R; furthermore, it is unknown whether splice variants of the same receptor engender the same or differential biased signalling.",
author = "Darren Riddy and Cook, {Anna Evelyn} and Natalie Diepenhorst and Sanja Bosnyak and Ryan Brady and {La Cour}, {Clotilde Mannoury} and Elisabeth Mocaer and Roger Summers and William Charman and Sexton, {Patrick Michael} and Arthur Christopoulos and Christopher Langmead",
year = "2016",
language = "English",
note = "ASCEPT-MPGPCR Joint Scientific Meeting 2016 : Therapeutic targeting: right place, right time, right effect, ASCEPT/MPGPCR 2016 ; Conference date: 27-11-2016 Through 30-11-2016",
url = "https://www.asceptasm.com/2016-annual-scientific-meeting/program-workshops/",

}

Riddy, D, Cook, AE, Diepenhorst, N, Bosnyak, S, Brady, R, La Cour, CM, Mocaer, E, Summers, R, Charman, W, Sexton, PM, Christopoulos, A & Langmead, C 2016, 'Isoform-specific bias of histamine H3 receptor agonists' ASCEPT-MPGPCR Joint Scientific Meeting 2016, Melbourne, Australia, 27/11/16 - 30/11/16, .

Isoform-specific bias of histamine H3 receptor agonists. / Riddy, Darren; Cook, Anna Evelyn; Diepenhorst, Natalie; Bosnyak, Sanja; Brady, Ryan; La Cour, Clotilde Mannoury; Mocaer, Elisabeth; Summers, Roger; Charman, William; Sexton, Patrick Michael; Christopoulos, Arthur; Langmead, Christopher.

2016. Poster session presented at ASCEPT-MPGPCR Joint Scientific Meeting 2016, Melbourne, Australia.

Research output: Contribution to conferencePosterOtherpeer-review

TY - CONF

T1 - Isoform-specific bias of histamine H3 receptor agonists

AU - Riddy, Darren

AU - Cook, Anna Evelyn

AU - Diepenhorst, Natalie

AU - Bosnyak, Sanja

AU - Brady, Ryan

AU - La Cour, Clotilde Mannoury

AU - Mocaer, Elisabeth

AU - Summers, Roger

AU - Charman, William

AU - Sexton, Patrick Michael

AU - Christopoulos, Arthur

AU - Langmead, Christopher

PY - 2016

Y1 - 2016

N2 - The histamine H3 receptor (H3R) is widely expressed in human brain and has been implicated in various pathologies, including Alzheimer’s disease, schizophrenia, dementia and Parkinson’s disease. The H3R is subject to extensive gene splicing that gives rise to a large number of functional and non-functional isoforms. G protein-coupled receptors (GPCRs) can adopt different ligand-induced conformations that give rise to biased signalling, however, this has not been studied for the H3R; furthermore, it is unknown whether splice variants of the same receptor engender the same or differential biased signalling.

AB - The histamine H3 receptor (H3R) is widely expressed in human brain and has been implicated in various pathologies, including Alzheimer’s disease, schizophrenia, dementia and Parkinson’s disease. The H3R is subject to extensive gene splicing that gives rise to a large number of functional and non-functional isoforms. G protein-coupled receptors (GPCRs) can adopt different ligand-induced conformations that give rise to biased signalling, however, this has not been studied for the H3R; furthermore, it is unknown whether splice variants of the same receptor engender the same or differential biased signalling.

M3 - Poster

ER -

Riddy D, Cook AE, Diepenhorst N, Bosnyak S, Brady R, La Cour CM et al. Isoform-specific bias of histamine H3 receptor agonists. 2016. Poster session presented at ASCEPT-MPGPCR Joint Scientific Meeting 2016, Melbourne, Australia.