Isoform-specific bias of histamine H3 receptor agonists

Research output: Contribution to conferencePosterpeer-review

Abstract

The histamine H3 receptor (H3R) is widely expressed in human brain and has been implicated in various pathologies, including Alzheimer’s disease, schizophrenia, dementia and Parkinson’s disease. The H3R is subject to extensive gene splicing that gives rise to a large number of functional and non-functional isoforms. G protein-coupled receptors (GPCRs) can adopt different ligand-induced conformations that give rise to biased signalling, however, this has not been studied for the H3R; furthermore, it is unknown whether splice variants of the same receptor engender the same or differential biased signalling.
Original languageEnglish
Publication statusPublished - 2016
EventASCEPT-MPGPCR Joint Scientific Meeting 2016: Therapeutic targeting: right place, right time, right effect - Melbourne Convention & Exhibition Centre, Melbourne, Australia
Duration: 27 Nov 201630 Nov 2016
https://www.asceptasm.com/2016-annual-scientific-meeting/program-workshops/

Conference

ConferenceASCEPT-MPGPCR Joint Scientific Meeting 2016
Abbreviated titleASCEPT/MPGPCR 2016
Country/TerritoryAustralia
CityMelbourne
Period27/11/1630/11/16
Internet address

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