Isavuconazole

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Abstract

Isavuconazole (Basilea Pharmaceutica, Basel, Switzerland) is a broad-spectrum prodrug triazole with efficacy against a range of medically important fungi including Aspergillus spp. and the Mucorales. Isavuconazonium (BAL-8557) is the water-soluble prodrug of isavuconazole (BAL-4815), which is the active moiety. The conversion to isavuconazole is rapid and complete. Isavuconazole is the newest member of the triazole class of antifungals and has an important role in the treatment of life-threatening invasive fungal diseases (IFDs).

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs
EditorsM. Lindsay Grayson
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Chapter158
Pages2858-2869
Number of pages12
Edition7th
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
Publication statusPublished - 2 Oct 2017

Cite this

Ananda-Rajah, M. R., Chang, C. C., & Slavin, M. A. (2017). Isavuconazole. In M. L. Grayson (Ed.), Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs (7th ed., pp. 2858-2869). CRC Press.