Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms?

Lv Wang, Manya T. Angley, Jacobus P. Gerber, Robyn L. Young, Damien V. Abarno, Ross A. McKinnon, Michael J. Sorich

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19 Citations (Scopus)

Abstract

An autism spectrum disorder (ASD) diagnosis is based on clinical behaviours as there are no validated biological diagnostic tools. Indolyl-3- acryloylglycine (IAG) is a chemical produced by gut microflora and there are conflicting reports as to whether urinary levels are elevated in children with ASD compared with controls. Urinary IAG levels in morning urine samples were statistically significantly higher in children with ASD whose caregivers reported the presence of chronic gastrointestinal (GI) disturbance than children with ASD without chronic GI disturbance. Urinary IAG, however, was not statistically significantly higher in children with ASD, compared with siblings or unrelated controls without ASD.

Original languageEnglish
Pages (from-to)596-603
Number of pages8
JournalBiomarkers
Volume14
Issue number8
DOIs
Publication statusPublished - Dec 2009
Externally publishedYes

Keywords

  • Autism spectrum disorder
  • Diagnosis
  • Gastrointestinal disturbance
  • Indolyl-3-acryloylglycine
  • Subtypes
  • Urinary biomarker

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