Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Belinda G. Vermey; Su Jen Chua; Mohammad Hadi Zafarmand; Rui Wang; Salvatore Longobardi; Evelyn Cottell; Francois Beckers; Ben W. Mol; Christos A. Venetis; Thomas D'Hooghe

doi:10.1016/j.rbmo.2019.06.013

Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Belinda G. Vermey
, Su Jen Chua
, Mohammad Hadi Zafarmand
, Rui Wang
, Salvatore Longobardi
, Evelyn Cottell
, Francois Beckers
, Ben W. Mol
, Christos A. Venetis
, Thomas D'Hooghe

Obstetrics & Gynaecology Monash Health

Research output: Contribution to journal › Review Article › Research › peer-review

54 Citations (Scopus)

Abstract

This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [r_w] = 0.791), day 5/6 embryos (r_w = 0.901), metaphase II oocytes (r_w = 0.988), oocytes exhibiting two pronuclei (r_w = 0.987) and euploid embryos (r_w = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.

Original language	English
Pages (from-to)	751-763
Number of pages	13
Journal	Reproductive BioMedicine Online
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/j.rbmo.2019.06.013
Publication status	Published - Nov 2019

Keywords

Embryo quality
Euploid
Oocyte number
Oocyte yield

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10.1016/j.rbmo.2019.06.013

285161705-oaFinal published version, 1.9 MB

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title = "Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis",

abstract = "This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95\% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95\% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95\% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.",

keywords = "Embryo quality, Euploid, Oocyte number, Oocyte yield",

author = "Vermey, \{Belinda G.\} and Chua, \{Su Jen\} and Zafarmand, \{Mohammad Hadi\} and Rui Wang and Salvatore Longobardi and Evelyn Cottell and Francois Beckers and Mol, \{Ben W.\} and Venetis, \{Christos A.\} and Thomas D'Hooghe",

year = "2019",

month = nov,

doi = "10.1016/j.rbmo.2019.06.013",

language = "English",

volume = "39",

pages = "751--763",

journal = "Reproductive BioMedicine Online",

issn = "1472-6483",

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T1 - Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

AU - Vermey, Belinda G.

AU - Chua, Su Jen

AU - Zafarmand, Mohammad Hadi

AU - Wang, Rui

AU - Longobardi, Salvatore

AU - Cottell, Evelyn

AU - Beckers, Francois

AU - Mol, Ben W.

AU - Venetis, Christos A.

AU - D'Hooghe, Thomas

PY - 2019/11

Y1 - 2019/11

N2 - This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.

AB - This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.

KW - Embryo quality

KW - Euploid

KW - Oocyte number

KW - Oocyte yield

UR - https://www.scopus.com/pages/publications/85072251717

U2 - 10.1016/j.rbmo.2019.06.013

DO - 10.1016/j.rbmo.2019.06.013

M3 - Review Article

AN - SCOPUS:85072251717

SN - 1472-6483

VL - 39

SP - 751

EP - 763

JO - Reproductive BioMedicine Online

JF - Reproductive BioMedicine Online

IS - 5

ER -

Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Abstract

Keywords

Access to Document

Other files and links

Modernizing the knowledge base for reproductive health care: Individual patient data meta-analysis as the new standard for evidence synthesis in reproductive health.

Cite this

Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Abstract

Keywords

Access to Document

Other files and links

Projects

Modernizing the knowledge base for reproductive health care: Individual patient data meta-analysis as the new standard for evidence synthesis in reproductive health.

Cite this