Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis

Belinda G. Vermey, Su Jen Chua, Mohammad Hadi Zafarmand, Rui Wang, Salvatore Longobardi, Evelyn Cottell, Francois Beckers, Ben W. Mol, Christos A. Venetis, Thomas D'Hooghe

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

This systematic review and meta-analysis determined the association between aspirated after ovarian stimulation and top/good quality embryos obtained in women undergoing ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI). MEDLINE, EMBASE, Scopus, CINAHL and Web of Science were searched for English-language publications on top/good-quality embryos at cleavage (day 2/3) and/or blastocyst (day 5/6) developmental stages, up to 18 November 2017. Twenty-eight studies (three prospective and 25 retrospective) reporting data on 291,752 assisted reproductive technology (ART) cycles were considered eligible. We confirmed a strong positive association between oocytes retrieved and top/good-quality day 2/3 embryos (weighted correlation coefficient [rw] = 0.791), day 5/6 embryos (rw = 0.901), metaphase II oocytes (rw = 0.988), oocytes exhibiting two pronuclei (rw = 0.987) and euploid embryos (rw = 0.851); P < 0.001 for all correlations (evaluated in subsets of the 17 studies). Data from 5657 cycles showed that the group with the most oocytes aspirated had the most top/good-quality day 2/3 embryos (pooled standardized mean differences (high [>15] versus low [<4] 1.91, 95% confidence interval [CI] 1.05–2.77, P < 0.0001; high versus medium [4–15] 1.15, 95% CI 0.74–1.55, P < 0.0001; medium versus low 1.41, 95% CI 0.79–2.03, P < 0.0001). Individual participant meta-analysis would enable accurate determination of these associations and other outcomes.

Original languageEnglish
Number of pages13
JournalReproductive BioMedicine Online
DOIs
Publication statusAccepted/In press - 3 Jul 2019

Keywords

  • Embryo quality
  • Euploid
  • Oocyte number
  • Oocyte yield

Cite this

Vermey, B. G., Chua, S. J., Zafarmand, M. H., Wang, R., Longobardi, S., Cottell, E., ... D'Hooghe, T. (Accepted/In press). Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis. Reproductive BioMedicine Online. https://doi.org/10.1016/j.rbmo.2019.06.013
Vermey, Belinda G. ; Chua, Su Jen ; Zafarmand, Mohammad Hadi ; Wang, Rui ; Longobardi, Salvatore ; Cottell, Evelyn ; Beckers, Francois ; Mol, Ben W. ; Venetis, Christos A. ; D'Hooghe, Thomas. / Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis. In: Reproductive BioMedicine Online. 2019.
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Is there an association between oocyte number and embryo quality? A systematic review and meta-analysis. / Vermey, Belinda G.; Chua, Su Jen; Zafarmand, Mohammad Hadi; Wang, Rui; Longobardi, Salvatore; Cottell, Evelyn; Beckers, Francois; Mol, Ben W.; Venetis, Christos A.; D'Hooghe, Thomas.

In: Reproductive BioMedicine Online, 03.07.2019.

Research output: Contribution to journalReview ArticleResearchpeer-review

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AU - Vermey, Belinda G.

AU - Chua, Su Jen

AU - Zafarmand, Mohammad Hadi

AU - Wang, Rui

AU - Longobardi, Salvatore

AU - Cottell, Evelyn

AU - Beckers, Francois

AU - Mol, Ben W.

AU - Venetis, Christos A.

AU - D'Hooghe, Thomas

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