Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways

Alicia Stievenard, Mathieu Mequinion, Zane B. Andrews, Alain Destée, Marie-Christine Chartier-Harlin, Odile Viltart, Christel C. Vanbesien-Mailliot

Research output: Contribution to journalReview ArticleOtherpeer-review

23 Citations (Scopus)


The gastro-intestinal peptide ghrelin has been assigned many functions. These include appetite regulation, energy metabolism, glucose homeostasis, intestinal motility, anxiety, memory or neuroprotection. In the last decade, this pleiotropic peptide has been proposed as a therapeutic agent in gastroparesis for diabetes and in cachexia for cancer. Ghrelin and its receptor, which is expressed throughout the brain, play an important role in motivation and reward. Ghrelin finely modulates the mesencephalic dopaminergic signaling and is thus currently studied in pathological conditions including dopamine-related disorders. Dopamine regulates motivated behaviors, modulating reward processes, emotions and motor functions to enable the survival of individuals and species. Numerous dopamine-related disorders including Parkinson's disease or eating disorders like anorexia nervosa involve altered ghrelin levels. However, despite the growing interest for ghrelin in these pathological conditions, global integrative studies investigating its role in brain dopaminergic structures are still lacking. In this review, we discuss the role of ghrelin on dopaminergic neurons and its relevance in the search for new therapeutics for Parkinson's disease- and anorexia nervosa-related dopamine deficits.

Original languageEnglish
Pages (from-to)255-275
Number of pages21
JournalNeuroscience and Biobehavioral Reviews
Publication statusPublished - Feb 2017


  • Anorexia nervosa
  • Dopamine
  • Ghrelin
  • Goal-directed action
  • Motivation
  • Parkinson's disease

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