TY - JOUR
T1 - Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
AU - Johnson, Richard J
AU - Kang, Duk-Hee
AU - Feig, Daniel
AU - Kivlighn, Salah
AU - Kanellis, John
AU - Watanabe, Susumu
AU - Tuttle, Katherine R
AU - Rodriguez-Iturbe, Bernardo
AU - Herrera-Acosta, Jaime
AU - Mazzali, Marilda
PY - 2003
Y1 - 2003
N2 - Abstracta??Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In
this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize
experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an
antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial
dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative
evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal
disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension
and to design human studies to address this controversy.
AB - Abstracta??Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In
this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize
experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an
antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial
dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative
evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal
disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension
and to design human studies to address this controversy.
UR - http://hyper.ahajournals.org/cgi/reprint/41/6/1183
U2 - 10.1161/01.HYP.0000069700.62727.C5
DO - 10.1161/01.HYP.0000069700.62727.C5
M3 - Article
SN - 0194-911X
VL - 41
SP - 1183
EP - 1190
JO - Hypertension
JF - Hypertension
IS - 6
ER -