Is the higher incidence of clozapine induced myocarditis in Australia due to awareness and monitoring?

Jessica L Dawson, Scott R Clark, Janet K Sluggett, Nicholas Procter, J Simon Bell

Research output: Contribution to journalLetterOtherpeer-review

14 Citations (Scopus)


We read with interest the recent case report and review of serious clozapine adverse reactions by Li et al. (2018). Clozapine induced myocarditis (CIM) is a potentially life-threatening adverse drug reaction (ADR). The authors attribute mortality in this case to CIM and suggest that screening via cardiac enzymes and inflammatory markers should be routine. Internationally, the incidence of CIM has been estimated at 0.07% to 0.7% (Cohen et al., 2012). In contrast, rates ranging from <0.1% to 8.5% have been reported in Australia, with highest incidence in single centre studies (Ronaldson et al., 2015).
Original languageEnglish
Pages (from-to)426-427
Number of pages2
JournalSchizophrenia Research
Publication statusPublished - 1 Nov 2018


  • Australia
  • Clozapine
  • Drug-related side effects and adverse reactions
  • Myocarditis

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