Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?

Max J. Cryle, James J. De Voss

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Abstract

Not the ferryl oxidant? The oxidation of thiafatty acids by P450 BM3 (CYP102A1) was shown to be consistent with oxidation by the ferric hydroperoxy species (Cpd 0) rather than the expected ferryl species (Cpd 1). This is the first indication that sulfur oxidation in a wildtype P450 occurs via the hydroperoxy species. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)8221-8223
Number of pages3
JournalAngewandte Chemie - International Edition
Volume45
Issue number48
DOIs
Publication statusPublished - 11 Dec 2006
Externally publishedYes

Keywords

  • Cytochromes
  • Enzyme catalysis
  • Oxidation
  • P450
  • Sulfur

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