Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 403 - 409 |
| Number of pages | 7 |
| Journal | Expert Opinion on Biological Therapy |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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Is specific HIV eradication from the brain possible or needed? / Brew, Bruce James; Gray, Lachlan Robert; Lewin, Sharon R; Churchill, Melissa.
In: Expert Opinion on Biological Therapy, Vol. 13, No. 3, 2013, p. 403 - 409.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Is specific HIV eradication from the brain possible or needed?
AU - Brew, Bruce James
AU - Gray, Lachlan Robert
AU - Lewin, Sharon R
AU - Churchill, Melissa
PY - 2013
Y1 - 2013
N2 - There is increasing interest in the possibility of eradication of HIV, given the recent case reports. However, it is not clear to what extent brain involvement by HIV poses a challenge to systemic eradication strategies. Areas covered: This review will outline the mechanisms of HIV latency, the various eradication strategies presently under consideration followed by a discussion of the issue of the frequency and severity of brain involvement by HIV. In those patients with HIV brain disease the challenges will be delineated as well as potential approaches to circumvent or minimise them. Expert opinion: Eradication of HIV from the brain using specific methodologies is likely only needed in some patients. However, both the identification of such patients and the details of the necessary methodologies require much more research. ? 2013 Informa UK, Ltd.
AB - There is increasing interest in the possibility of eradication of HIV, given the recent case reports. However, it is not clear to what extent brain involvement by HIV poses a challenge to systemic eradication strategies. Areas covered: This review will outline the mechanisms of HIV latency, the various eradication strategies presently under consideration followed by a discussion of the issue of the frequency and severity of brain involvement by HIV. In those patients with HIV brain disease the challenges will be delineated as well as potential approaches to circumvent or minimise them. Expert opinion: Eradication of HIV from the brain using specific methodologies is likely only needed in some patients. However, both the identification of such patients and the details of the necessary methodologies require much more research. ? 2013 Informa UK, Ltd.
UR - http://informahealthcare.com/doi/pdf/10.1517/14712598.2013.748029
U2 - 10.1517/14712598.2013.748029
DO - 10.1517/14712598.2013.748029
M3 - Article
VL - 13
SP - 403
EP - 409
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
SN - 1471-2598
IS - 3
ER -