TY - JOUR
T1 - Is fetal growth restriction associated with a more severe maternal phenotype in the setting of early onset pre-eclampsia? A retrospective study
AU - Weiler, Jane M
AU - Tong, Stephen
AU - Palmer, Kirsten Rebecca
PY - 2011
Y1 - 2011
N2 - Background: Both pre-eclampsia and fetal growth restriction are thought to result from abnormal placental implantation in early pregnancy. Consistent with this shared pathophysiology, it is not uncommon to see growth restriction further confound the course of pre-eclampsia and vice versa. It has been previously suggested that superimposed growth restriction is associated with a more severe pre-eclamptic phenotype, however this has not been a consistent finding. Therefore, we set out to determine whether the presence of fetal growth restriction among women with severe early-onset pre-eclampsia was associated with more severe maternal disease compared to those without a growth-restricted fetus. Methods and Findings: We undertook a retrospective cohort study of women presenting to a tertiary hospital with severe early-onset pre-eclampsia (
AB - Background: Both pre-eclampsia and fetal growth restriction are thought to result from abnormal placental implantation in early pregnancy. Consistent with this shared pathophysiology, it is not uncommon to see growth restriction further confound the course of pre-eclampsia and vice versa. It has been previously suggested that superimposed growth restriction is associated with a more severe pre-eclamptic phenotype, however this has not been a consistent finding. Therefore, we set out to determine whether the presence of fetal growth restriction among women with severe early-onset pre-eclampsia was associated with more severe maternal disease compared to those without a growth-restricted fetus. Methods and Findings: We undertook a retrospective cohort study of women presenting to a tertiary hospital with severe early-onset pre-eclampsia (
UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026937
U2 - 10.1371/journal.pone.0026937
DO - 10.1371/journal.pone.0026937
M3 - Article
SN - 1932-6203
VL - 6
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e26937
ER -