Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide hepcidin has emerged as the body s key irons store regulator. The long postulated erythroid regulator of iron , however, remained elusive. Last year, evidence was provided, that a previously described myokine myonectin may also function as the long sought erythroid regulator of iron. Myonectin was therefore re-named erythroferrone . This editorial provides a brief discussion on the two functions of erythroferrone and also briefly considers the emerging potential role of transferrin receptor 2 in erythropoiesis.