Is erythroferrone finally the long sought-after systemic erythroid regulator of iron?

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Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide hepcidin has emerged as the body s key irons store regulator. The long postulated erythroid regulator of iron , however, remained elusive. Last year, evidence was provided, that a previously described myokine myonectin may also function as the long sought erythroid regulator of iron. Myonectin was therefore re-named erythroferrone . This editorial provides a brief discussion on the two functions of erythroferrone and also briefly considers the emerging potential role of transferrin receptor 2 in erythropoiesis.
Original languageEnglish
Pages (from-to)78 - 82
Number of pages5
JournalWorld Journal of Biological Chemistry
Issue number3
Publication statusPublished - 2015

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