Is CD20 positive plasma cell myeloma a unique clinicopathological entity? A study of 40 cases and review of the literature

George Grigoriadis, Michael Gilbertson, Neil Came, David A Westerman, Frank Fellepa, Nick Jene, Peter Chapple, Surender Juneja

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aims: A number of clinicopathological features have been attributed to the CD20 positive subset of plasma cell myeloma (PCM). CD20 is an appealing therapeutic target given the success with monoclonal antibody regimens in a spectrum of B cell lymphomas. To date, a small number of reports have described CD20+ PCM as a unique subset, and these are not conclusive, especially taking into consideration reporting bias. This study aims to further identify the clinicopathological features of CD20 + PCM. Methods: A retrospective analysis of all newly diagnosed PCM between 2003 and 2010 was undertaken. Trephine material was retrieved and reviewed for CD20, and for positive cases an extended immunohistochemical (IHC) panel including cyclin D1 was subsequently performed. Results: The review of our 40 cases and those described in the literature demonstrated that these are heterogeneous with regard to clinical features, morphology, biochemical features, immunophenotype, and cytogenetics. Conclusion: Based on our study and review of the literature, CD20 + PCM cases represent a heterogeneous disease and not a unique clinicopathological entity. ? 2012 Royal College of Pathologists of Australasia.
Original languageEnglish
Pages (from-to)552 - 556
Number of pages5
JournalPathology
Volume44
Issue number6
DOIs
Publication statusPublished - 2012

Cite this

Grigoriadis, George ; Gilbertson, Michael ; Came, Neil ; Westerman, David A ; Fellepa, Frank ; Jene, Nick ; Chapple, Peter ; Juneja, Surender. / Is CD20 positive plasma cell myeloma a unique clinicopathological entity? A study of 40 cases and review of the literature. In: Pathology. 2012 ; Vol. 44, No. 6. pp. 552 - 556.
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abstract = "Aims: A number of clinicopathological features have been attributed to the CD20 positive subset of plasma cell myeloma (PCM). CD20 is an appealing therapeutic target given the success with monoclonal antibody regimens in a spectrum of B cell lymphomas. To date, a small number of reports have described CD20+ PCM as a unique subset, and these are not conclusive, especially taking into consideration reporting bias. This study aims to further identify the clinicopathological features of CD20 + PCM. Methods: A retrospective analysis of all newly diagnosed PCM between 2003 and 2010 was undertaken. Trephine material was retrieved and reviewed for CD20, and for positive cases an extended immunohistochemical (IHC) panel including cyclin D1 was subsequently performed. Results: The review of our 40 cases and those described in the literature demonstrated that these are heterogeneous with regard to clinical features, morphology, biochemical features, immunophenotype, and cytogenetics. Conclusion: Based on our study and review of the literature, CD20 + PCM cases represent a heterogeneous disease and not a unique clinicopathological entity. ? 2012 Royal College of Pathologists of Australasia.",
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Is CD20 positive plasma cell myeloma a unique clinicopathological entity? A study of 40 cases and review of the literature. / Grigoriadis, George; Gilbertson, Michael; Came, Neil; Westerman, David A; Fellepa, Frank; Jene, Nick; Chapple, Peter; Juneja, Surender.

In: Pathology, Vol. 44, No. 6, 2012, p. 552 - 556.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Is CD20 positive plasma cell myeloma a unique clinicopathological entity? A study of 40 cases and review of the literature

AU - Grigoriadis, George

AU - Gilbertson, Michael

AU - Came, Neil

AU - Westerman, David A

AU - Fellepa, Frank

AU - Jene, Nick

AU - Chapple, Peter

AU - Juneja, Surender

PY - 2012

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N2 - Aims: A number of clinicopathological features have been attributed to the CD20 positive subset of plasma cell myeloma (PCM). CD20 is an appealing therapeutic target given the success with monoclonal antibody regimens in a spectrum of B cell lymphomas. To date, a small number of reports have described CD20+ PCM as a unique subset, and these are not conclusive, especially taking into consideration reporting bias. This study aims to further identify the clinicopathological features of CD20 + PCM. Methods: A retrospective analysis of all newly diagnosed PCM between 2003 and 2010 was undertaken. Trephine material was retrieved and reviewed for CD20, and for positive cases an extended immunohistochemical (IHC) panel including cyclin D1 was subsequently performed. Results: The review of our 40 cases and those described in the literature demonstrated that these are heterogeneous with regard to clinical features, morphology, biochemical features, immunophenotype, and cytogenetics. Conclusion: Based on our study and review of the literature, CD20 + PCM cases represent a heterogeneous disease and not a unique clinicopathological entity. ? 2012 Royal College of Pathologists of Australasia.

AB - Aims: A number of clinicopathological features have been attributed to the CD20 positive subset of plasma cell myeloma (PCM). CD20 is an appealing therapeutic target given the success with monoclonal antibody regimens in a spectrum of B cell lymphomas. To date, a small number of reports have described CD20+ PCM as a unique subset, and these are not conclusive, especially taking into consideration reporting bias. This study aims to further identify the clinicopathological features of CD20 + PCM. Methods: A retrospective analysis of all newly diagnosed PCM between 2003 and 2010 was undertaken. Trephine material was retrieved and reviewed for CD20, and for positive cases an extended immunohistochemical (IHC) panel including cyclin D1 was subsequently performed. Results: The review of our 40 cases and those described in the literature demonstrated that these are heterogeneous with regard to clinical features, morphology, biochemical features, immunophenotype, and cytogenetics. Conclusion: Based on our study and review of the literature, CD20 + PCM cases represent a heterogeneous disease and not a unique clinicopathological entity. ? 2012 Royal College of Pathologists of Australasia.

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